Inflammation Expert Flashcards

1
Q

Which of the subq TNF inhibitors are latex-free?

A

Cimzia and the citrate-free version of Humira

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2
Q

Which of the TNF inhibitors contain latex?

A

Enbrel, and Simponi pen and PFS

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3
Q

Which of the interleukin inhibitors contain latex?

A

Cosentyx, Stelara

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4
Q

Which meds for inflammation have a REMS, and what is it for?

A
  • Siliq for suicidal ideation
  • Tysabri TOUCH program for PML risk
  • Gattex to increase awareness of neoplastic growth, colon polyp growth, GI obstruction, and billiary/pancreatic disorders
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5
Q

Which meds used for inflammation have a contraindication, and what is it?

A
  • Siliq is CI in Chrohn’s Disease
  • Krystexxa is CI in G6PD deficiency
  • Otrexup/Rosuvo is pregnancy category X
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6
Q

Which meds have a loading dose for RA?

A
  • Cimzia
  • Simponi IV
  • Remicade
  • Orencia (optional LD)
  • Rituxan
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7
Q

Which inflammations meds are LDD?

A
  • Kineret
  • Arcalyst
  • Ilaris
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8
Q

Which meds have to be administered by a healthcare provider?

A
  • Cimzia vials medical benefit
  • Ilaris
  • Stelara vial may be administered at MDO under medical benefit, or at home under pharmacy benefit
  • Ilumya can only be administered at MDO, and billed under either medical or pharmacy benefit
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9
Q

Which meds have recommended infusion times?

A
  • Simponi, Orencia, Entyvio over 30 minutes
  • Tysabri over 1 hour
  • Remicade and Krystexxa over ≥2 hours
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10
Q

Which medications have dose adjustments, and what are they?

A
  • Remicade mod-severe CHF (NYHA Class III-IV) ,≤ 5mg/kg dose
  • Kineret, CrCl <30mL/min QOD dosing
  • Actemra and Kevzara, dose reduction or d/c for abnormal liver function test, neutropenia or thrombocytopenia
  • Xeljanz, Rinvoq and Olumiant, dose reduction or d/c for renal or hepatic impairment, anemia, lymphopenia or neutropenia
  • Xeljanz dose reduction or d/c w/strong CYP3A4 or CYP2C19 inhibitors
  • Xeljanz/Rinvoq avoid use with CYP3A4 inducers
  • Olumian, avoid use w/OAT3 inhibitors
  • Otezla for CrCl<30mL/min, final dose is 30mg QAM (3, 2, then 1qd)
  • Gattex, CrCl <60mL/min, decrease dose by 50% qd (to 0.025mg/kg daily)
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11
Q

Which medications should be discontinued upon a timed lack-of response?

A
  • Siliq, d/c if no response in 12-16 weeks
  • Entyvio, d/c if no benefit by week 14
  • Tysabri, d/c if no benefit by week 12
  • Krystexxa, consider d/c if UA levels increase to >6 mg/dL
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12
Q

Which infusions require pre-medications?

A
  • Remicade: antihistamine, APAP and/or steroids
  • Rituxan: antistamime, APAP, methylprednisolone 100mg IV 30 minutes prior to infusion
  • Krystexxa: antinhistamine and steroids
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13
Q

Which inflammation medication may exacerbate COPD, and what are its indications?

A

Orencia

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14
Q

Which medications may lead to intestinal perforations, and what are their indications?

A
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15
Q

What are the indications and doses for Cimzia?

A
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16
Q

What are the doses and indications for Enbrel?

A
17
Q

What are the indications and doses for Humira?

A
18
Q

What are the indications and dosing schedules for Simponi?

A
19
Q

What are the indications and doses for Remicade?

A
20
Q

Which meds are IL23 inhibitors, and what disease do they all treat?

A
  • Tremfya, Skyrizi and Ilumya all treat plaque psoriasis
  • Tremfya also treats psoratic arthritis
  • Ilumya is stable at room temp for > 30 days