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Inflammation 20% > Inflammation Drugs > Flashcards

Inflammation Drugs Flashcards

1
Q
  • abatacept
  • T-cell inhibitor
  • RA, PsA, JIA
  • maltose in IV formulation
  • may exacerbate COPD
A

Orencia

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2
Q
  • natalizumab
  • Selective Adhesion-Molecule Inhibitor
  • CD
  • REMS=CD-Touch for PML risk
  • BBW for PML
A

Tysabri

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3
Q
  • ixekizumab
  • IL-17a inhibitor
  • AS, PsA, PP, nr-axSpA
  • may trigger IBD
A

Taltz

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4
Q
  • infliximab
  • TNF inhibitor
  • RA w/methotrexate, CD, UC, PsA, PP, AS
A

Remicade

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5
Q
  • certolizumab pegol
  • TNF inhibitor
  • Subq
  • RA, AS, nr-axSpA, PsA, PP, CD
  • latex free
A

-Cimzia

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6
Q
  • dupilumab
  • IL-4 inhibitor
  • AD, off-label for asthma
  • ocular SEs
A

Dupixent

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7
Q
  • upadacitinib
  • JAK inhibitor
  • RA
  • SE: diverticulitis
  • BBW: serious infections, malignancy
A

Rinvoq

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8
Q
  • guselkumab
  • IL-23 inhibitor
  • PsA, PP
  • supplied as PFS or One-Press Patient Controlled Injector device
  • latex free
A

Tremfya

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9
Q
  • ustekinumab
  • IL 12/23 inhibitor
  • PP, PsA, CD, UC
  • latex in needle cover and guard
  • SE of posterior leukoencephalopathy syndrome and squamous cell carcinoma
  • BCG vaccine at least 1yr apart
A

Stelara

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10
Q
  • baracitinib
  • JAK inhibitor
  • RA
  • SE: diverticulitis
  • BBW: thrombosis, serious infections, malignancy
A

Olumiant

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11
Q
  • etanercept
  • TNF inhibitor
  • RA, AS, PsA, PP, pJIA, ped PP
  • supplied as vial, PFS, Sureclick and mini w/auto touch
A

Enbrel

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12
Q
  • teduglutide
  • GLP-2 Analog
  • subq
  • Short Bowel Syndrome
  • monitor fluid status with CVD pts
  • REMS: increase awareness of noeplastic growth, colon polyp growth, GI obstruction, and biliary/pancreatic disorders
A

Gattex

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13
Q
  • tofacitinib
  • JAK inhibitor
  • RA, PsA, UC
  • SE: diverticulitis
  • BBW: serious infection, malignancy
  • XR: inert tablet shell in the stool
A

Xeljanz

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14
Q
  • tocilizumab
  • IL-6 inhibitor
  • subq and IV
  • RA, pJIA, sJIA (IV), GCA (subQ)
  • monitor for s/s of demyelination & GI perforation
A

Actemra

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15
Q
  • Rilonacept
  • IL-1 inhibitor
  • CAPS
  • reconstitution stable at RT < 3 hours
A

Arcalyst

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16
Q
  • anakinra
  • IL-1 inhibitor
  • RA, NOMID
  • Discard if unrefrigerated for 12 hours
A

Kineret

17
Q
  • belimumab
  • B-lymphocyte stimulator protein inhibitor
  • IV, subq
  • Systemic Lupus Erythematosis
  • AA may respond less
  • rare SE of PML
A

Benlysta

18
Q
  • secukinumab
  • IL-17a inhibitor
  • PP, PsA, AS, nr-axSpA
  • latex in caps
  • may trigger IBD
A

Cosentyx

19
Q
  • tildrakizumab
  • IL-23 inhibitor
  • PP
  • in-office administration only
A

Ilumya

20
Q
  • apremilast
  • PDE-4 inhibitor
  • PO
  • Behchet disease, PP, PsA
  • contains lactose
  • weight loss, diarrhea, suicidal ideation
A

Otezla

21
Q
  • sarilumab
  • IL-6 inhibitor
  • RA
  • monitor for s/s of GI perforation
A

Kevzara

22
Q
  • pegloticase
  • Urate-oxidase enzyme
  • IV
  • gout
  • CI in G6PD deficiency
  • BBW: anaphylaxis, G6PD Deficiency
A

Krystexxa

23
Q
  • omalizumab
  • Anti-IgG monoclonal antibody
  • subq
  • Chronic Ideapathic Urticaria
  • BBW: anaphylaxis
A

Xolair

24
Q
  • brodalumab
  • IL-17a inhibitor
  • PP
  • contraindicated in CD
  • REMS for suicidal ideation
A

Siliq

25
Q
  • rituximab
  • anti-CD20 Monoclonal Antibody
  • IV
  • RA, pemphigus vulgaris
  • BBW: HBV reactivación, PML
A

Rituxan

26
Q
  • golimumab
  • TNF inhibitor
  • Subq, IV
  • RA w/methotrexate, PsA, AS, UC
A

Simponi

27
Q
  • Canakinumab
  • IL-1 inhibitor
  • CAPS, AOSD, FMF, HIDS/MKD, TRAPS, sJIA
  • reconstitution stable RT <1hr or refrigerator <4 hrs
A

Ilaris

28
Q
  • adalimumab
  • TNF inhibitor
  • RA, PsA, AS, Uveitis, PP, CD (adult), UC, CD (ped), JIA
  • citrate free = latex free
A

Humira

29
Q
  • vedolizumab
  • Integrin Receptor Antagonist
  • CD, UC
A

Entyvio

Inflammation 20% (2 decks)

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