Inflammation Drugs

Question 1

• abatacept
• T-cell inhibitor
• RA, PsA, JIA
• maltose in IV formulation
• may exacerbate COPD

Answer 1

Orencia

Question 2

• natalizumab
• Selective Adhesion-Molecule Inhibitor
• CD
• REMS=CD-Touch for PML risk
• BBW for PML

Answer 2

Tysabri

Question 3

• ixekizumab
• IL-17a inhibitor
• AS, PsA, PP, nr-axSpA
• may trigger IBD

Answer 3

Taltz

Question 4

• infliximab
• TNF inhibitor
• RA w/methotrexate, CD, UC, PsA, PP, AS

Answer 4

Remicade

Question 5

• certolizumab pegol
• TNF inhibitor
• Subq
• RA, AS, nr-axSpA, PsA, PP, CD
• latex free

Answer 5

-Cimzia

Question 6

• dupilumab
• IL-4 inhibitor
• AD, off-label for asthma
• ocular SEs

Answer 6

Dupixent

Question 7

• upadacitinib
• JAK inhibitor
• RA
• SE: diverticulitis
• BBW: serious infections, malignancy

Answer 7

Rinvoq

Question 8

• guselkumab
• IL-23 inhibitor
• PsA, PP
• supplied as PFS or One-Press Patient Controlled Injector device
• latex free

Answer 8

Tremfya

Question 9

• ustekinumab
• IL 12/23 inhibitor
• PP, PsA, CD, UC
• latex in needle cover and guard
• SE of posterior leukoencephalopathy syndrome and squamous cell carcinoma
• BCG vaccine at least 1yr apart

Answer 9

Stelara

Question 10

• baracitinib
• JAK inhibitor
• RA
• SE: diverticulitis
• BBW: thrombosis, serious infections, malignancy

Answer 10

Olumiant

Question 11

• etanercept
• TNF inhibitor
• RA, AS, PsA, PP, pJIA, ped PP
• supplied as vial, PFS, Sureclick and mini w/auto touch

Answer 11

Enbrel

Question 12

• teduglutide
• GLP-2 Analog
• subq
• Short Bowel Syndrome
• monitor fluid status with CVD pts
• REMS: increase awareness of noeplastic growth, colon polyp growth, GI obstruction, and biliary/pancreatic disorders

Answer 12

Gattex

Question 13

• tofacitinib
• JAK inhibitor
• RA, PsA, UC
• SE: diverticulitis
• BBW: serious infection, malignancy
• XR: inert tablet shell in the stool

Answer 13

Xeljanz

Question 14

• tocilizumab
• IL-6 inhibitor
• subq and IV
• RA, pJIA, sJIA (IV), GCA (subQ)
• monitor for s/s of demyelination & GI perforation

Answer 14

Actemra

Question 15

• Rilonacept
• IL-1 inhibitor
• CAPS
• reconstitution stable at RT < 3 hours

Answer 15

Arcalyst

Question 16

• anakinra
• IL-1 inhibitor
• RA, NOMID
• Discard if unrefrigerated for 12 hours

Answer 16

Kineret

Question 17

• belimumab
• B-lymphocyte stimulator protein inhibitor
• IV, subq
• Systemic Lupus Erythematosis
• AA may respond less
• rare SE of PML

Answer 17

Benlysta

Question 18

• secukinumab
• IL-17a inhibitor
• PP, PsA, AS, nr-axSpA
• latex in caps
• may trigger IBD

Answer 18

Cosentyx

Question 19

• tildrakizumab
• IL-23 inhibitor
• PP
• in-office administration only

Answer 19

Ilumya

Question 20

• apremilast
• PDE-4 inhibitor
• PO
• Behchet disease, PP, PsA
• contains lactose
• weight loss, diarrhea, suicidal ideation

Answer 20

Otezla

Question 21

• sarilumab
• IL-6 inhibitor
• RA
• monitor for s/s of GI perforation

Answer 21

Kevzara

Question 22

• pegloticase
• Urate-oxidase enzyme
• IV
• gout
• CI in G6PD deficiency
• BBW: anaphylaxis, G6PD Deficiency

Answer 22

Krystexxa

Question 23

• omalizumab
• Anti-IgG monoclonal antibody
• subq
• Chronic Ideapathic Urticaria
• BBW: anaphylaxis

Answer 23

Xolair

Question 24

• brodalumab
• IL-17a inhibitor
• PP
• contraindicated in CD
• REMS for suicidal ideation

Answer 24

Siliq

Question 25

• rituximab
• anti-CD20 Monoclonal Antibody
• IV
• RA, pemphigus vulgaris
• BBW: HBV reactivación, PML

Answer 25

Rituxan

Question 26

• golimumab
• TNF inhibitor
• Subq, IV
• RA w/methotrexate, PsA, AS, UC

Answer 26

Simponi

Question 27

• Canakinumab
• IL-1 inhibitor
• CAPS, AOSD, FMF, HIDS/MKD, TRAPS, sJIA
• reconstitution stable RT <1hr or refrigerator <4 hrs

Answer 27

Ilaris

Question 28

• adalimumab
• TNF inhibitor
• RA, PsA, AS, Uveitis, PP, CD (adult), UC, CD (ped), JIA
• citrate free = latex free

Answer 28

Humira

Question 29

• vedolizumab
• Integrin Receptor Antagonist
• CD, UC

Answer 29

Entyvio