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MOD Test 1 > Inflammation and Repair (tables) > Flashcards

Inflammation and Repair (tables) Flashcards

1
Q

onset of acute inflammation

A

fast: minutes or hours

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2
Q

onset of chronic inflammation

A

slow: days

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3
Q

cellular infiltrate acute inflammation

A

mainly neutrophils

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4
Q

cellular infiltrate chronic inflammation

A

monocytes/macrophages and lymphocytes

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5
Q

tissue injury and fibrosis with acute inflammation

A

usually mild and self-limited

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6
Q

tissue injury and fibrosis with chronic inflammation

A

often severe and progressive

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7
Q

local and systemic signs of acute inflammation

A

prominent

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8
Q

local and systemic signs of chronic inflammation

A

less

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9
Q

histamine source

A

mast cells, basophils, platelets

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10
Q

histamine action

A

vasodilation, increased vascular permeability, endothelial activation

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11
Q

prostaglandins source

A

mast cells, leukocytes

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12
Q

prostaglandins action

A

vasodilation, pain, fever

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13
Q

leukotrienes source

A

mast cells, leukocytes

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14
Q

leukotrienes action

A

increased vascular permeability, chemotaxis, leukocyte adhesion, and activation

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15
Q

Cytokines (TNF, IL-1, IL-6) source

A

macrophages, endothelial cells, mast cells

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16
Q

Cytokines (TNF, IL-1, IL-6) action

A

Local: endothelial activation (expression of adhesion molecules

Systemic: fever, metabolic abnormalities, hypotension (shock)

17
Q

chemokines source

A

leukocytes, activated macrophages

18
Q

chemokines action

A

chemotaxis, leukocyte activation

19
Q

platelet-activating factor source

A

leukocytes, mast cells

20
Q

platelet-activating factor action

A

vasodilation, increased vascular permeability, leukocyte adhesion, chemotaxis, degranulation, oxidative burst

21
Q

complement source

A

plasma (produced in liver)

22
Q

complement action

A

leukocyte chemotaxis and activation, direct target killing (membrane attack complex), vasodilation (mast cell stimulation)

23
Q

kinins source

A

plasma (produced in liver)

24
Q

kinins action

A

increased vascular permeability, smooth muscle contraction, vasodilation, pain

MOD Test 1 (3 decks)

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