Important Cytokines Flashcards
1
Q
IL-1
A
- secreted by macrophages
- causes fever and acute inflammation
- activates endothelium to express adhesion molecules
- induces chemokine secretion to recruit WBC
2
Q
IL-6
A
- secreted by macrophages
- causes fever
- production of acute phase response
3
Q
IL-8
A
- secreted by macrophages
- major chemotactic factor for neutrophils (clear infection)
“clean up on IL-8”
4
Q
IL-12
A
- secreted by macrophages, dendritic cells
- increased production IFN-gamma
5
Q
TNF-α
A
- secreted by macrophages
- mediates septic shock
- activates endothelium
- causes WBC recruitment, vascular leak
- causes cachexia in malignancy
6
Q
IL-2
A
- secreted by all T-cells
- stimulates growth of helper, cytotoxic, and regulatory T cells
- stimulates growth NK cells
7
Q
IL-3
A
- secreted by all T-cells
- supports growth and differentiation of bone marrow stem cells
- functions like GM-CSF
8
Q
IFN-γ
A
- secreted from T lymphocytes and NK cells
- activates macrophages
9
Q
IL-4
A
- secreted from Th2 cells
- induces differentiation into Th2 cells
- promotes growth of B cells
- enhance class switching to IgE and IgG
10
Q
IL-5
A
- secreted from Th2 cells
- promotes differentiation of B cells
- enhances class switching to IgA
- stimulates growth and differentiation of eosinophils
11
Q
IL-10
A
- secreted from Th2 cells
- modulates inflammatory response
- decreases expression of MHC class II and Th1 cytokines
- inhibits activated macrophages and dendritic cells
- secreted by Tregs
- attenuates immune response with TGF-β
12
Q
IL-17
A
- secreted by T lymphcytes
- recruitment of neutrophils and monocytes
