Inflammation And Repair Flashcards
PGE2 functions
Vasodilation, pain and fever
PGI2 functions
Vasodilation
Inhibition of platelet aggregation
Leukotrienes are synthesised in leukocytes from which chemical ?
Arachidonic avid
Leucotrienes are synthesised in which enzyme
Lipoocygenase
Leucotrienes LTB4 functions
Chemotaxis
Activation of neutrophil adhesion molecules
Leucotrienes LTC4, D4, E4 functions
Vasoconstriction
Increased vascular permeability
Bronchoconstriction
Bradykinin is a product of
Kinin system activation by activated factor XII
Bradykinin functions
Vasodilation
Which interleukin is primarily responsible for increased liver synthesis of acute phase reactants ?
IL6
Source of histamine
Mast cells
Function of histamine
Vasodilation
Function of nitric oxide
Vasodilation
Which drug inhibits lipooxygenase
Zileuton
Which drug is a leucotriene receptor antagonist?
Montelukast
Most variable phase of cell cycle
G1 phase
Most critical phase of the cel cycle
G1 to S phase transition
Control proteins for G1 to S phase
Cyclin dependent kinase 4 (cdk4)
Cyclin D
Genes controlling G1 to S phase
RB1 and p53 suppressor genes
Which vitamin is required in the post translational modification Of tropo collagen ?
Ascorbic acid
Defect of type I and type III collagen synthesis
Ehlers-Danlos syndrome (EDS)
Characterised by hyper mobile joints, aortic dissection(most common cause of death), Mittal valve prolapse, poor wound healing
