Inflammation And Repair

Question 1

PGE2 functions

Answer 1

Vasodilation, pain and fever

Question 2

PGI2 functions

Answer 2

Vasodilation

Inhibition of platelet aggregation

Question 3

Leukotrienes are synthesised in leukocytes from which chemical ?

Answer 3

Arachidonic avid

Question 4

Leucotrienes are synthesised in which enzyme

Answer 4

Lipoocygenase

Question 5

Leucotrienes LTB4 functions

Answer 5

Chemotaxis

Activation of neutrophil adhesion molecules

Question 6

Leucotrienes LTC4, D4, E4 functions

Answer 6

Vasoconstriction
Increased vascular permeability
Bronchoconstriction

Question 7

Bradykinin is a product of

Answer 7

Kinin system activation by activated factor XII

Question 8

Bradykinin functions

Answer 8

Vasodilation

Question 9

Which interleukin is primarily responsible for increased liver synthesis of acute phase reactants ?

Answer 9

IL6

Question 10

Source of histamine

Answer 10

Mast cells

Question 11

Function of histamine

Answer 11

Vasodilation

Question 12

Function of nitric oxide

Answer 12

Vasodilation

Question 13

Which drug inhibits lipooxygenase

Answer 13

Zileuton

Question 14

Which drug is a leucotriene receptor antagonist?

Answer 14

Montelukast

Question 15

Most variable phase of cell cycle

Answer 15

G1 phase

Question 16

Most critical phase of the cel cycle

Answer 16

G1 to S phase transition

Question 17

Control proteins for G1 to S phase

Answer 17

Cyclin dependent kinase 4 (cdk4)

Cyclin D

Question 18

Genes controlling G1 to S phase

Answer 18

RB1 and p53 suppressor genes

Question 19

Which vitamin is required in the post translational modification Of tropo collagen ?

Answer 19

Ascorbic acid

Question 20

Defect of type I and type III collagen synthesis

Answer 20

Ehlers-Danlos syndrome (EDS)
Characterised by hyper mobile joints, aortic dissection(most common cause of death), Mittal valve prolapse, poor wound healing