Gastroinestinal Disorders

Question 1

Celiac disease pathogenesis

Answer 1

Inappropriate Tcell and IgA mediated response against gluten in genetically predisposed individuals

Question 2

Which HLA is celiac disease associated with ?

Answer 2

HLA-DQ2 in 95% cases

HLA-DQ8 in 5% cases

Question 3

Which enzyme in lamina propria plays a pivotal role in producing celiac disease?

Answer 3

Tissue Transglutaminase (tTG)

Question 4

Important diagnostic antibodies for Celiac disease

Answer 4

Anti tTG IgA antibodies (most important ), IgG antibodies

Antiendomysial antibodies (EMA) IgA antibodies

Antigliadin IgA and IgG antibodies

Question 5

Which clinical conditions is celiac disease associated with ?

Answer 5

Dermatitis herpetiformis  (most important )
Other autoimmune disorders 
Type 1 DM
Hashimotos 
IgA deficiency

Question 6

Microscopic features of celiac disease

Answer 6

Villous atrophy

Hyperplastic glands with intense lymphocytic infiltration