inflammation Flashcards

1
Q

What does itits mean?

A

inflammatory process

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2
Q

What’s always present with infection?

A

inflammation (never the other way round)

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3
Q

What is the medical term for redness:

A

erhthema

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4
Q

Causes of inflammation include:

A

heat/cold, radiation/chemical, electrical, mechanical, microbial, ischemic/hypoxia injuries and any disorders in the immune response

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5
Q

What is the medical term for swelling:

A

edema

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6
Q

What are the cardinal S/S of inflammation:

A

erythema, edema, heat, pain, loss of function

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7
Q

What are the four phases of the inflammatory responses:

A

vascular, cellular, exudate formation, healing process

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8
Q

Cell injury caused:

A

cell death, vasoconstriction…

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9
Q

When cells briefly vasoconstrict, release of histamine and other chemicals are released by injured cells, vessels dilate, increased capillary permeability, capillary fluid enter tissue spaces occurs during what response of inflammation:

A

vascular response

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10
Q

What inflammation response occurs when WBCs become active to clean up the wound and initiate further healing process

A

cellular response

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11
Q

WBCs of the cellular response will release:

A

Neutrophils (1st phase), monocytes, lymphocytes

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12
Q

What phagocytic WBC will arrive 3-7 days, upon entrance of tissue spaces they become macrophage, will accumulate and fuse together to form a giant cell that’s encapsulated by collagen to form a granuloma (such as TB), they can multiply and stay in the tissue for weeks.

A

monocytes

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13
Q

What WBC is produced by the bonemarrow, arrives later at injured site, their primary role is humoral and cell-mediated immunity, and will differentiate into B/T lymphocytes

A

lymphocytes

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14
Q

What are the chemical mediators of inflammation:

A

complement system, prostaglandins, thromboxane, and leukotriens

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15
Q

Which chemical mediator has an enzyme cascade pathway, enhanced phagocytosis, vascular premeability, chemotaxis, and cellular lysis:

A

complement system

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16
Q

What chemical mediator causes: produced fever and Arachidonic Acid in the cell membrane, are potent vasodilators, pro-inflammatory, inhibits platelet/neutrophil aggregation, and pain:

A

prostaglandins

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17
Q

What chemical mediator is a powerful vasoconstrictor (skin pallor at injured site), potent HTN agent, platelet aggregates (thrombosis) and is an enzyme found in platelets:

A

thromboxane

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18
Q

What chemical mediator is SRS-A, constricts smooth muscles of bronchi and increases capillary permeability leading to airway edema:

A

leukotrienes

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19
Q

When fluid and leukocytes that move from circulation to the site of energy is defined as:

A

exudate formation

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20
Q

Exudate caused by skin blisters, pleural effusion, or is seen in early stages of inflammation or when injury is mild is define as:

A

serous

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21
Q

Exudate that causes a runny nose associated with URI is called:

A

Catarrhal

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22
Q

Exudate caused by adhesions:

A

Fibrinous

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23
Q

Exudate caused by boils, abscess, cellulitis is called:

A

purulent (pus)

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24
Q

Exudate that’s caused by hematoma is called:

A

hemorrhagic

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25
What chemical is triggers fever:
cytokines
26
What promotes synthesis/secretions of prostaglandins, increases thermostatic set point of core temp, hypothalamus activates the autonomic nervous system, and epinephrine is released to increase metabolic rate:
cytokines which all = fever
27
What are the types of inflammation:
Acute, subacute, chronic
28
When most injuries heal by connective tissue is defined:
repair
29
What are the three intentions of repair:
primary, secondary, and tertiary
30
This intention occurs when wound margins are well approximated (surgical/paper cut wounds):
primary intention
31
What are the three phases of primary intention:
initial, granulation, maturation phase/scar contraction
32
This phase of primary intention occurs lasts 3-5 days, edges of wound are approximated, cell migration occurs, acute inflammatory response occurs, macrophages, fibrin clots:
initial phase
33
This phase of the primary intention lasts 5-3 wks, is considered to be fibroblastic, proliferative, reconstructive, migration of fibroblasts, pink and vascular wounds:
granulation phase
34
This phase of primary intention overlaps granulation, begins by 7th day of injury and continues for months/years, collagen fibers are organized/remodeling, contraction of healing area/shortening or tightening of muscle/skin/joint/ligament, wound is mature, avascular, and pale:
maturation phase
35
What intention occurs when edges cannot be approximated or brought together caused by trauma, ulceration, or infection, bigger wounds will have gaping wound edges, more granulation occurs:
secondary intention
36
Which intention is a delayed suturing of a wound in which 2 layers of granulation tissues are sutured together
f
37
When most injuries heal by connective tissue is defined:
repair
38
What are the three intentions of repair:
primary, secondary, and tertiary
39
This intention occurs when wound margins are well approximated (surgical/paper cut wounds):
primary intention
40
What are the three phases of primary intention:
initial, granulation, maturation phase/scar contraction
41
This phase of primary intention occurs lasts 3-5 days, edges of wound are approximated, cell migration occurs, acute inflammatory response occurs, macrophages, fibrin clots:
initial phase
42
This phase of the primary intention lasts 5-3 wks, is considered to be fibroblastic, proliferative, reconstructive, migration of fibroblasts, pink and vascular wounds:
granulation phase
43
This phase of primary intention overlaps granulation, begins by 7th day of injury and continues for months/years, collagen fibers are organized/remodeling, contraction of healing area/shortening or tightening of muscle/skin/joint/ligament, wound is mature, avascular, and pale:
maturation phase
44
What intention occurs when edges cannot be approximated or brought together caused by trauma, ulceration, or infection, bigger wounds will have gaping wound edges, more granulation occurs:
secondary intention
45
Which intention is a delayed suturing of a wound in which 2 layers of granulation tissues are sutured together
f
46
When most injuries heal by connective tissue is defined:
repair
47
What are the three intentions of repair:
primary, secondary, and tertiary
48
This intention occurs when wound margins are well approximated (surgical/paper cut wounds):
primary intention
49
What are the three phases of primary intention:
initial, granulation, maturation phase/scar contraction
50
This phase of primary intention occurs lasts 3-5 days, edges of wound are approximated, cell migration occurs, acute inflammatory response occurs, macrophages, fibrin clots:
initial phase
51
This phase of the primary intention lasts 5-3 wks, is considered to be fibroblastic, proliferative, reconstructive, migration of fibroblasts, pink and vascular wounds:
granulation phase
52
This phase of primary intention overlaps granulation, begins by 7th day of injury and continues for months/years, collagen fibers are organized/remodeling, contraction of healing area/shortening or tightening of muscle/skin/joint/ligament, wound is mature, avascular, and pale:
maturation phase
53
What intention occurs when edges cannot be approximated or brought together caused by trauma, ulceration, or infection, bigger wounds will have gaping wound edges, more granulation occurs:
secondary intention
54
Which intention is a delayed suturing of a wound in which 2 layers of granulation tissues are sutured together
f
55
A wound that is severing of vessels or tissue:
laceration
56
When most injuries heal by connective tissue is defined:
repair
57
What are the three intentions of repair:
primary, secondary, and tertiary
58
This intention occurs when wound margins are well approximated (surgical/paper cut wounds):
primary intention
59
What are the three phases of primary intention:
initial, granulation, maturation phase/scar contraction
60
This phase of primary intention occurs lasts 3-5 days, edges of wound are approximated, cell migration occurs, acute inflammatory response occurs, macrophages, fibrin clots:
initial phase
61
This phase of the primary intention lasts 5-3 wks, is considered to be fibroblastic, proliferative, reconstructive, migration of fibroblasts, pink and vascular wounds:
granulation phase
62
This phase of primary intention overlaps granulation, begins by 7th day of injury and continues for months/years, collagen fibers are organized/remodeling, contraction of healing area/shortening or tightening of muscle/skin/joint/ligament, wound is mature, avascular, and pale:
maturation phase
63
What intention occurs when edges cannot be approximated or brought together caused by trauma, ulceration, or infection, bigger wounds will have gaping wound edges, more granulation occurs:
secondary intention
64
Which intention is a delayed suturing of a wound in which 2 layers of granulation tissues are sutured together
tertiary intention
65
A wound that's a scraping of skin or mucous membranes:
abrasion
66
a wound that's crushing of tissue cells that cause hemorrhage into skin is called:
contusion (bruise)
67
This type of wound that piercing of body structure or organ:
puncture
68
This type of wound is a surgical cutting is called:
incision
69
This wound color is seen in stage II pressure ulcers, skin tear, surgical wounds that are able to heal by secondary intention, can be partial thickness/second degree burns and Tx is:transparent film dressing and antimicrobials
Red wound
70
What color wound sees nonviable tissue/slough, dressing will be a gel or foam, Tx will be continual cleansing, removal of nonviable tissue, absorption of excessive drainage
Yellow
71
This color wound will present eschar, can be full-thickness/3rd degree burns, stage 3-4 pressure ulcers, gangrenous ulcers, Tx consists of debridement:
Black wound
72
What are some factors that delay tissue healing:
nutritional deficiencies (C, protein, Zinc), inadequate blood supply, cortocosteriods, infection, smoking, mechanical friction, advanced age, obesity, DM, poor general health, anemia
73
What are some complications of wound healing:
adhesions, contracture, evisceration, dehiscence, excess granulation, fistula formation, infections, hemorrhage, hypertrophic scarring, keloid formation
74
The removal of foreign material of dead or damage tissue of the wound is defined as:
Debridement
75
A wet to dry or wet to moist dressing is what type of debridement:
mechanical debridement
76
What type of debridement when there's large amounts of nonviable tissue are present & pt is septic:
surgical debridement
77
What type of debridement sees occlusive dressing, promotes softening of dry eschar, used in open wounds w/no infection present, is the slowest method of healing:
Autolytic debridement
78
What type of debridement involves enzymatic dressings to necrotic tissue , covered w/moist dressing, causes fibrin lysis, WOCN will have orders or charting:
Enzymatic debridement
79
A vacuum-assisted wound closure or wound-vac is defined as what type of therapy:
Negative-Pressure therapy
80
What type of wound therapy uses suction to remove drainage and speed wound healing, dressing may contain sponge packing, transparent dressing may be used, and tubing from wound is attached to a pump to create a type of _______ pressure:
Negative-pressure wound therapy
81
What type of wound therapy delivers 100% O2 at increased atmospheric pressures in an enclosed chamber, O2 may be given at 1.5-3 times the normal atmospheric pressure, and allows for O2 to diffuse into serum rather than RBCs, and transports to tissues:
Hyperbaric O2 Therapy (works really well for DM pts)