inflammation Flashcards
What does itits mean?
inflammatory process
What’s always present with infection?
inflammation (never the other way round)
What is the medical term for redness:
erhthema
Causes of inflammation include:
heat/cold, radiation/chemical, electrical, mechanical, microbial, ischemic/hypoxia injuries and any disorders in the immune response
What is the medical term for swelling:
edema
What are the cardinal S/S of inflammation:
erythema, edema, heat, pain, loss of function
What are the four phases of the inflammatory responses:
vascular, cellular, exudate formation, healing process
Cell injury caused:
cell death, vasoconstriction…
When cells briefly vasoconstrict, release of histamine and other chemicals are released by injured cells, vessels dilate, increased capillary permeability, capillary fluid enter tissue spaces occurs during what response of inflammation:
vascular response
What inflammation response occurs when WBCs become active to clean up the wound and initiate further healing process
cellular response
WBCs of the cellular response will release:
Neutrophils (1st phase), monocytes, lymphocytes
What phagocytic WBC will arrive 3-7 days, upon entrance of tissue spaces they become macrophage, will accumulate and fuse together to form a giant cell that’s encapsulated by collagen to form a granuloma (such as TB), they can multiply and stay in the tissue for weeks.
monocytes
What WBC is produced by the bonemarrow, arrives later at injured site, their primary role is humoral and cell-mediated immunity, and will differentiate into B/T lymphocytes
lymphocytes
What are the chemical mediators of inflammation:
complement system, prostaglandins, thromboxane, and leukotriens
Which chemical mediator has an enzyme cascade pathway, enhanced phagocytosis, vascular premeability, chemotaxis, and cellular lysis:
complement system
What chemical mediator causes: produced fever and Arachidonic Acid in the cell membrane, are potent vasodilators, pro-inflammatory, inhibits platelet/neutrophil aggregation, and pain:
prostaglandins
What chemical mediator is a powerful vasoconstrictor (skin pallor at injured site), potent HTN agent, platelet aggregates (thrombosis) and is an enzyme found in platelets:
thromboxane
What chemical mediator is SRS-A, constricts smooth muscles of bronchi and increases capillary permeability leading to airway edema:
leukotrienes
When fluid and leukocytes that move from circulation to the site of energy is defined as:
exudate formation
Exudate caused by skin blisters, pleural effusion, or is seen in early stages of inflammation or when injury is mild is define as:
serous
Exudate that causes a runny nose associated with URI is called:
Catarrhal
Exudate caused by adhesions:
Fibrinous
Exudate caused by boils, abscess, cellulitis is called:
purulent (pus)
Exudate that’s caused by hematoma is called:
hemorrhagic
What chemical is triggers fever:
cytokines
What promotes synthesis/secretions of prostaglandins, increases thermostatic set point of core temp, hypothalamus activates the autonomic nervous system, and epinephrine is released to increase metabolic rate:
cytokines which all = fever
What are the types of inflammation:
Acute, subacute, chronic
When most injuries heal by connective tissue is defined:
repair
What are the three intentions of repair:
primary, secondary, and tertiary
This intention occurs when wound margins are well approximated (surgical/paper cut wounds):
primary intention
What are the three phases of primary intention:
initial, granulation, maturation phase/scar contraction
This phase of primary intention occurs lasts 3-5 days, edges of wound are approximated, cell migration occurs, acute inflammatory response occurs, macrophages, fibrin clots:
initial phase