Inflammation

Question 1

What are the five cardinal signs of inflammation?

Answer 1

Heat, Redness, Swelling, Pain and Loss of Function

Question 2

What are the four steps in the inflammation process?

Answer 2

Change in circulation in blood, changes in vessel wall permeability, WBC response, release of soluble mediators

Question 3

How do arterioles react to injurious stimulus?

Answer 3

vasoconstiction for a few seconds followed by vasodialation

Question 4

Why do the vessel walls of capillaries increase permeability in response to inflammation?

Answer 4

1. Increase pressure inside congested vessels 2. lowering of O2 2/2 slowing of circulation 3. adhesion of leukocytes and platelets to endothelial cells 4. release of soluble mediators

Question 5

The mediators of inflammation belong to what two classes?

Answer 5

Plasma derived and cell derived

Question 6

What mediator of inflammation is released from platelets and mast cells and basophils and provokes a contraction of endothelial cells of venules?

Answer 6

Histamine

Question 7

What does the contraction of endothelial cells caused by histamine cause?

Answer 7

increase in permeability, which leads to fluids in the interstitial spaces

Question 8

what mediator of inflammation increases vascular permeability and can also incite pain?

Answer 8

Bradykinin