Inflammation

Question 1

What do antiinflammatory agents do

Answer 1

block or alter chemical reactions to stop one or more of the symptoms

Question 2

Considerations for children

Answer 2

aspirin can lead to Reye’s syndrome, no ibuprofen <6 months, Tylenol is the most used and requires careful dosing

Question 3

Considerations for adults

Answer 3

careful about OTC overdosing, avoid while pregnant and nursing, use nondrug measures when possible, report OTC use to providers

Question 4

Considerations for older adults

Answer 4

Increased susceptibility to CNS and GI effects, some NSAIDs may require dosing adjustments

Question 5

Salicylate example

Answer 5

aspirin

Question 6

COX-1 Receptor location

Answer 6

site of action is in all tissues

Question 7

COX-1 Receptor effects

Answer 7

synthesize inflammatory prostaglandins and causes fever, maintains renal function, promotes gastric mucosa integrity, promotes vascular hemostasis

Question 8

COX-1 Receptor effects of blocking

Answer 8

decreases swelling, pain, inflammation, and fever

Question 9

COX-2 Receptors

Answer 9

site of action is induced by stimuli at the site of inflammation

Question 10

COX-2 Receptors effect

Answer 10

vasodilation, increases pain and inflammation

Question 11

COX-2 Receptors effects of blocking

Answer 11

decreases pain and inflammation

Question 12

COX-2 Receptors harmful effects of blocking

Answer 12

prevents protective vasodilation allowing platelet clumping leading to stroke or MI, Stevens-Johnson skin reaction