inflamation Flashcards
IL-4
b cell growth factor and selector of isotype, especially IgE
IL-6
controls differentiation of B cells, induces acute phase proteins
TNF alpha / beta
activates macrophages, granulocytes, cytotoxic cells, enhance mhc class 1 expression, induce cacheixa, pyrexia, acute phase proteins
4 x chemotactic agents for macrophages
c5a
cytokines
acdtivated t helper lyphocyte secretions, lymphokines
matrix product
long standing chronic colitis is most likely crohn’s disease if
marked submucosal odema and lymphocytic infiltration
focal epitheloid cell granulomas are seen in a mucosal bx
3x predominate cell types in granulomatous inflamation
macrophages
epitheloid cells
giant cells
examples of granulomatous inflamation
tb, sarcoidosis
syphilis, brucellosis, cat-scratch disease
crohn’s disease, primary bilary cirrhosis
4 x examples of granuloma formation
crohn’s disease
primary biliary cirrhosis
sarcoidosis
cat scratch lymphadenitis
what is paf?
phospholipid derived g-protein coupled .
15994 – Fibroblasts proliferate and migrate during the healing process in response to the direct action of
1: cytokines
2: expression of adhesion molecules on endothelial cells
3: leukotrienes
4: platelet activating factor (PAF)
cytokines
25980 – Increase in vascular permeability may account for the oedema in
1: acute anaphylaxis
2: adult respiratory distress syndrome
3: serum sickness
4: lymphoedema
1: acute anaphylaxis
2: adult respiratory distress syndrome
3: serum sickness
23974 – The mononuclear cells in an acute inflammatory exudate
1: morphologically resemble lymphocytes
2: are derived from stem cells in the germinal centres of lymph nodes
3: undergo chemotaxis in response to IgE antibody
4: are mainly transformed blood monocytes
4: are mainly transformed blood monocytes
three functions of complement
inflammation, opsonization and phagocytosis and cell lysis
