Infertility Flashcards

1
Q

Define infertility

A

Inability to become pregnant after 12 months

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2
Q

How many US couples are affected by infertility?

A

1 in 8

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3
Q

What is secondary infertility?

A

When a person has one pregnancy and then has trouble becoming pregnant again
-More common than primary

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4
Q

What criteria determines if a woman should be assessed earlier for infertility?

A

-Over 35
-History of oligomenorrhea or amenorrhea
-Uterine/tubal disease or endometriosis
-Partner known to be subfertile

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5
Q

Between what ages does optimal fertility occur?

A

20 and 30

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6
Q

True or False: The male should be checked first when exploring infertility?

A

True

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7
Q

What are 4 non-pharmacologic treatment options for infertility?

A
  1. Gain or lose weight
  2. Avoid caffeine, smoking, alcohol, and illicit drugs
  3. Reduce stress
  4. “Expectant management”
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8
Q

What are the situations in which weight should be gained to help treat infertility?

A

-Hypothalamic anovulation
-BMI < 20

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9
Q

What are the situations in which weight should be lost to help treat infertility?

A

-High BMI
-Insulin resistance

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10
Q

What do urine ovulation predictor kits measure?

A

Detect surge in LH levels

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11
Q

When should urine ovulation predictor kits be used?

A

Use around time of suspected ovulation
–Test morning urine daily

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12
Q

What does a positive result on a urine ovulation predictor kit indicate?

A

Indicates ovulation in next 18-36hours with peak fertility generally in 2 days

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13
Q

How long does a woman’s fertile window last?

A

6 days

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14
Q

How long does sperm live after ejaculation?

A

1-2 days, up to 5 days

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15
Q

What is the lifespan of an egg after ovulation?

A

12-24 hours

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16
Q

How can cervical mucus be used to predict ovulation?

A

-Most fertile when mucus is clear, slippery, and stretchy
**Dry mucus means not fertile

17
Q

When should a basal body temperature be taken?

A

Every morning before rising from bed or eating/drinking

18
Q

How does ovulation affect basal body temperature?

A

Ovulation marks an increase by 0.3-0.5 degrees F
-Occurs 1-2 days after the LH surge
–After ovulation, high progesterone levels lead to increased body temp for 10 days

19
Q

How does pregnancy affect basal body temperature?

A

When pregnancy occurs the basal body temperature remains high until the placenta takes over

20
Q

What is the first FDA approved birth control app?

A

Natural Cycle

21
Q

What does the OvuSense device measure? (vaginal monitoring)

A

Intravaginal core body temperature every 5 minutes during sleep

22
Q

What is a benefit of the vaginal monitoring technique?

A

Beneficial in women with irregular periods

23
Q

When should women <35 yo undergo an infertility evaluation?

A

If unable to become pregnant after 12 months of frequent, unprotected intercourse

24
Q

When should women 35-40 yo undergo an infertility evaluation?

A

If unable to become pregnant after 6 months of frequent, unprotected intercourse

25
When should women >40 yo undergo an infertility evaluation?
If unable to become pregnant in less than 6 months with frequent, unprotected intercourse
26
What are the three pharmacologic treatments for infertility?
1. Controlled ovarian hyperstimulation 2. Gonadotropins with or without IUI 3. Assisted reproductive techniques
27
What medications are used for controlled ovarian hyperstimulation?
Aromatase inhibitors: --Letrozole (Femara) --Anastrozole (Arimidex)
28
How do gonadotropins work?
Develop multiple follicles by increasing FSH
29
What are some important points about Human Chorionic Gonadotropin?
-Triggers ovulation -Similar to LH -Inject at end of ovulation -2 Kinds: Recombinant hCG + Urinary hCG -Timing or injection is important -IM or subcutaneous
30
How does intrauterine insemination work (IUI)?
-Deliver washed sperm into uterine cavity with catheter -less invasive -less expensive
31
How does IVF work?
-Surgical retrieval of matured eggs from ovaries and fertilized in vitro -Embryos transferred back to uterus 3-5 days after fertiliztion *Extremely expensive
32
How does intracytoplasmic sperm injection (ICSI) work?
-Single sperm injected into egg to achieve fertilization **Overcomes severe male factor infertility -In conjunction with IVF
33
What are the possible complications of infertility treatment?
-Ovarian hyperstimulation syndrome (OHSS) -Risk of cancers -Multiple births