Infective Endocarditis

Question 1

Acute rheumatic fever is followed by an infection from which bacteria?

Answer 1

Group A Strep Pharyngeal Infection

Question 2

What is the mechanism of acute rheumatic fever

Answer 2

Autoimmune response to step antigens (streptolysin O and DNAse B) - cross reaction to myocardial tissue antigens

Question 3

Which population is most at risk for acute rheumatic fever?

Answer 3

Kids

Question 4

What is required to diagnose Acute Rheumatic Fever?

Answer 4

1. Preceding Group A Strep
2. Two Major Jones criteria or
3. One major and two minor Jones criteria

Question 5

What are the major Jones Criteria?

Answer 5

• Migratory polyarthritis
• Pancarditis
• Subcutaneous nodules
• Erythema marginatum
• Sydenham’s Chorea

Question 6

What are the minor Jones Criteria?

Answer 6

Fever
Arthralgia
Increase in acute phase reactants