Adrenergic Drugs Flashcards
Which adrenoceptor is responsible for contraction of peripheral vasculature, smooth muscle contraction and increased BP?
Alpha 1
Which terminal does Alpha2 regulate?
Presynaptic.
Regulates neurotransmitter release.
Which Beta receptor is not affected much by NE?
Beta2.
Has higher affinity for Epinephrine vs NE.
Which endogenous catecholamine is a full agonist for both alpha and beta receptors?
Epinephrine
What is another name for epinephrine?
Adrenaline
What are the affects of epinephrine on alpha1 receptors?
Increased resistance > higher BP
What are the affects of epinephrine on beta1 receptors?
Direct cardiac stimulation > higher BP
Positive inotropy and chronotropy
What is inotropic referring to?
Force or speed of contraction of muscles
Chronotropic refers to
Heart Rate
Which catecholamine drugs mimic the effect of sympathetic nervous system?
Sympathomimetic Drugs
Epinephrine effect on beta2 receptors
Smooth muscle relaxation
Which catecholamine results in a compensatory vagal reflex to overcome direct positive chronotropy?
Norepinephrine (noradrenaline)
Since does not effect B2 - there isn’t a balance, requiring the body to react with a vagal reflex.
“zoline” refers to what kind of drug?
Sympathomimetic direct alpha1 agonists
Used as topical nasal decongestants
Which sympathomimetic B2 selective agonist can be used to treat asthma?
Albuterol
Salmeterol
Why does dobutamine, a beta1 selective agonist, increase cardiac output with less reflex tachycardia?
Lacks B2 stimulated venous dilation
