Infectious Mononucleosis

Question 1

Define Infectious Mononucleosis

Answer 1

Glandular fever, caused 90% by EBV
-glandular mononucleosis is when EBV
followed by latent infection,

Question 2

Aetiology and risk factors of Infectious Mononucleosis

Answer 2

EBV is cause of 90% of it, and transmitted by saliva-and can be shed 15 months after onset of disease

risk factor
15-24 age
Kissing, sexual behaviour

Question 3

Epidiemology of Infectious Mononucleosis

Answer 3

500 cases in 100000, which isn’t that common
90% of adults seem to have a latent infection

15-24 age most common

Question 4

Signs and Sx of Infectious Mononucleosis

Answer 4

Pharangytis (pain on swallow, red throat)
Fever
Cervical lymphadenopathy
malaise
splenomegaly
Rash after being given penicillin
Myalgia

usually initially thought to be tonsillitis (much more common)-but as patient says its not improving, start thinking glandular fever

Question 5

Investigations of Infectious Mononucleosis

Answer 5

FBC-anemaia, thrombocytopenia, lymphocytosis
Heterophile antibodies
EBV specific AB
LFT-can be raised

Question 6

Management of Infectious Mononucleosis

Answer 6

Self limiting with no real treatment-supportive

Hydration, antipyrexic, pain killers

warn that it can take months to fully resolve
And that its very infectious so care

Question 7

Complications of Infectious Mononucleosis

Answer 7

Abx induced rash
Splenic rupture-go to A%E
airway blockage
1% get neuro issues
chronic active disease

Question 8

Prognosis of Infectious Mononucleosis

Answer 8

Very very good, very rare cases of splenic rupture, airway block

but very common to get post infective chronic fatigue syndrome