Infectious Diseases Flashcards
What is the name of the New World Screw Worm?
Cochliomyia hominivorax (Control - Sterile flies)
What is the name of the Old World Screw Worm?
Chrysomya bezziana
What is unique about the infestation of the screw worm makes it different from other blow flies?
Maggots feed on live tissue
What is the definition of drift as it pertains to flu viruses?
Small changes (mutations) that can lead to changes in the surface H & A proteins
What is the definition of shift as it pertains to flu viruses?
Abrupt major changes in flu viruses resulting in entirely new H & A proteins (new subtype that may be able to infect humans)
What is the prioritization of zoonotic disease in the US?
- Zoonotic Flu Viruses
- Salmonellosis
- West Nile Virus
- Plague
- Emerging Coronaviruses
- Rabies
- Brucellosis
- Lyme Disease
What are the zoonotic diseases that are prioritized by the US?
- Flu
- Salmonella
- West Nile Virus
- Plague
- Emerging Coronavirus
- Rabies
- Brucellosis
- Lyme Disease
What is American Foulbrood?
Paenibacillus larvae
- spore former (40 year survival)
- affects all brood types
- vegetative form is gram + rod
What is European Foulbrood?
Melissococcus plutonius
- Can be treated with oxytetracycline
- stress disease
- No spores, gram +
What is Chalkbrood?
Ascosphaera apis (fungus)
- weakens hive (decrease honey)
- all larval types
What is Sacbrood virus?
Sacbrood virus is caused by the sacbrood virus (Iflavirus) which affects worker bee larvae thought to be infected by consuming contaminated water, pollen or nectar.
Weakens hive
What causes adult bee paralysis?
Chronic bee paralysis virus (CBPV) causes a disease characterized by trembling, flightless, and crawling bees, while Acute bee paralysis virus (ABPV) is commonly detected in apparently healthy colonies, usually associated to Varroa destructor.
Pollen and nectar from toxic plants (buttercup, Laurel, Jasmine and others)
What is Nosema?
caused by two species of microsporidian parasites (a type of spore forming fungus) called Nosema apis and Nosema ceranae
Guts of workers, queens and drones
Infected bees usually defecate inside the hives, leaving yellow or yellowish excrement stains on top bars of frames, bottom board, combs, as well as the inside and outside of the hive. Bees infected with Nosema apis also show signs of dysentery and pay poor attention to brood rearing, turning to guard and foraging duties undertaken by older bees. Hypopharyngeal glands of infected EHB lose the ability to produce royal jelly that is fed to brood. Sick bees with distended abdomens crawl in front of the beehives with their wings spread out.
What is the Varroa destructor mite?
The parasitic mite, Varroa destructor, is beekeepers’ public enemy #1. This parasite is present in all honey bee colonies throughout the U.S and most of the world. Varroa harm the bees both by feeding on the developing and adult bees but also by vectoring viruses while they feed.
Deformed wings
What is the name of the honey bee tracheal mite?
Ascarapis woodi - effects adult bees
What is the name of the Small Hive Beetle?
Athina tumida - feed on honey, brood, pollen
What is the name of the honey bee louse?
Braula coeca - minimal threat
What is the name of the wax moth larvae that damage honey combs?
Galleria mellonella
What do Influenza Types A and B cause?
Seasonal epidemics of disease (flu season)
Which is the only flu type to cause pandemics?
A
What type of illness does flu type C cause?
Mild illness in people, not likely epidemics
What species does influenza D mostly affect?
Cattle
How many Hemagglutinin Subtypes are there?
18
How many Neuraminidase Subtypes are there?
11
When does viral resassortment occur?
Viruses swap entire gene segments
How are FLU viruses detected in respiratory secretions?
- Rapid Influenza Diagnostic Tests (immunoassay with increased specificity)
- Rapid Molecular Tests (detect nuclei acids by amplification - increased sensitivity as compared to RIDTs)
- RTPCR, Viral Culture and immunofluorescence (isolation and sequencing)
What is the prioritization of zoonotic diseases in the US?
1) Flu
2) Salmonellosis
3) West Nile Virus
4) Plague
5) Emerging Coronaviruses
6) Rabies
7) Brucellosis
8) Lyme Disease
What are the characteristics of low pathogenicity avian influenza viruses?
Usually asymptomatic (H5 & H7 can become HPAI)
What are the characteristics of high pathogenicity avian influenza viruses?
Highly fatal with rapid die off (H5 & H7)
What species do avian influenza viruses circulate in?
Aquatic birds, domestic poultry, swine, horses, dogs, bats and humans (detected in whales, seals, foxes and cats)
What Viral Diseases do Aedes aegypti mosquitos transmit?
Chikungunya
EEE (Can carry VEE)
Dengue
Yellow Fever
Zika
West Nile
What Viral Diseases do Aedes albopictus mosquitos transmit?
Chikungunya
EEE
Dengue
Yellow Fever
Zika
What Viral Diseases do Culex spp of mosquitos transmit?
West Nile
Japanese Encephalitis
St. Louis Encephalitis
What Viral Diseases do Aedes triseriatus mosquitos transmit?
La Crosse Encephalitis Virus
What viral diseases do Haemagogus mosquitos transmit?
Yellow Fever
What are the major consequential diseases the fleas transmit?
Plaque (Yersinia Pestis)
Murine Typhus (Rickettsia typhi - Endemic Typhus)
Which type of typhus do chiggers transmit?
Orientia tsutsugamushi (scrub typhus)
What are the main organisms that lead to visceral larval migrans?
Toxocara canis
Toxocara cati
Baylisascaris procyonis
Name the 3 equine encephalitis viruses, their family and their main vector
EEE Togavirus Culiseta melanura (culex species mostly)
WEE Togavirus Culex and others
VEE Togavirus Culex and others
What is the lifecycle of the small fluke (Nanophyetus Salminicola) that can be infected with the bacteria Neorickettsia helminthoeca?
What is the lifecycle of these organisms Schistosoma haematobium, S. japonicum, and S. mansoni that cause Schistosomiasis?
(2nd to Malaria in amount of people effects > 200million/year)
What is the lifecycle of Clonorchis sinensis, a trematode also known as the Chinese or Oriental liver fluke (eating raw freshwater fish - infect liver, gallbladder, bile duct)
What is the lifecycle of the Fish Tapeworm (Diphyllobothrium Latum) (Largest Human Tapeworm)?
What is the lifecycles of the Cattle Tapeworm (T. saginata) and the Pig Tapeworm (T. solium) - cysticercosis?
What is the lifecycle of cryptosporidium cyclospora (coccidian)?
What is the lifecycle of the malarial parasite?
What is heartland virus (type, transmission, species and symptoms in people)?
Family = bunyaviridae
Genus = phlebovirus
Transmitted by Amblyoma americanum
Species Effected - Racoons, white-tailed deer, horses, humans
People Symptoms = fever, fatigue, anorexia, decreased platelets, decreased WBCs and increased liver enzymes
What is heartwater (how is it transmitted, species effected, clinical signs and disease forms)?
- Bacteria Ehrlichia (formerly Cowdria)
ruminantium) (Africa, Sahara, Madagascar, Carribean) - Family Anaplasmataceae and Order Rickettsiales
- Transmission - Amblyoma Ticks
- Species - cattle, sheep, goats, white-tailed deer
- Clinical Signs - Fever 107, anorexia, listlessness, labored respiration (very fatal - 90%)
- Forms - peracute, acute, subacute and subclinical (possibly nervous form)
What are the resistance characteristics of R-type ACSSuT in strains of Salmonella Typhimurium?
Resistant to Ampicillin, chloramphenicol, streptomycin, sulphonamides and tetracyclines
What is Porcine Epidemic Diarrhea (Coronaviruses) /Transmissible Gastroenteritis-Like Virus?
Genus Alphacoronavirus within the family Coronaviridae
PED causes diarrhea in a large portion of swine.
Epidemic and endemic forms
Vaccines available
What is Peste des Petits Ruminants?
- Genus - Morbillivirus
- Family - Paramixoviridae (Similar to Rinderpest)
- Fatal goat plague (small ruminants)
- Vaccine available
- Depression, fever, discharge from eyes, nose, sores in the mouth, disturbed breathing and cough, foul smelling diarrhea and death
- Direct Contact
What is Rabbit Hemorrhagic Disease (RHDV2)?
- Genus - Lagovirus /Family - Caliciviridae
- Spread by direct contact and indirect (food, fomites, carcasses)
- Present in urine, feces and respiratory secretions
- Survives a long time in the environment
- Reportable
- No vaccines in this country (only during outbreak - killed vaccine on a conditional license)
- There is a live vaccine not licensed in this country at all
- Good biosecurity
What is vesicular stomatitis?
- Genus - vasiculovirus
- Family - Rhabdoviridae
- Species - Horses, Cattle, Swine, Sheep, Goats, Llamas, Alpacas, HUMANS
- Increased morbidity and rare mortality
- Spread - insects, animal movements, fomites
What is equine infectious anemia?
- Genus - Lentivirus
- Family - Retroviridae
- Only horses
- NO human health risk
- Spread - insect bites, needles, mare to foal
- Incubation - 7-45 days (carry for life)
- Prevention best option, no vaccine
- Coggins and if positive confirmatory testing
- Acute, Chronic, Inapparent
What is Equine Viral Arteritis Virus?
- Genus - Alphaarterivirus
- Family - Arteriviridae
- Abortions (previously unexposed mares cane have abortion rates of 70%)
- Many non-clinical
- Signs - decreased fertility, abortions, fever, depression, anorexia, edema (limb, prepuce, mammary), hives, conjunctivitis
- Spread - close contact, breeding, fomites (stallions can be long term carriers)
- Vaccine - modified live prior to breeding
What is Malignant Catarrhal Fever?
- Family - Herpesviridae
- Subfamily - Gammaherpesvirinae
- Genus - Macavirus
- Ruminant gamma herpes viruses including Alcelaphine gammaherpesvirus 1 and Ovine gammaherpesvirus 2
- Lymphoproliferative disease, fever, oral and nasal erosions, centripetal corneal opacity
- Typically transmitted from pregnant or recently-lambed sheep or goats (reservoir hosts) to cattle (susceptible species)
- Separate susceptible species
- Not zoonotic
What is Bovine Ephemeral Fever?
- Family - Rhabdoviridae
- Genus - Ephemerovirus
- Species - Cattle, water buffalo, yak (Africa Mostly)
- Clinical Signs - decreased productivity, fever, depression, serous or mucoid discharge, salivation, shivering (short duration - 10-11 days max)
- Serology - often cross-reacts to other viruses
- Transmission - arthropods
What families of viruses are carried by culicoides biting midges?
Orbivirus, Orthobunyaviruses, Rhabdoviruses
What is the incubation period for ASF?
4-19 days
What is the incubation period for CSF?
2-14 days
What is the incubation period for HPAI?
Up to 21 days
What is the incubation period for FMD?
2-14 days
What is the incubation period for vND?
2-6 days
What are the components of the disease FIREWALL in the US?
- US border protection
- State entry requirements
- Source herd health status
- Quarantine procedures
What are the Key Areas in a Biosecurity Plan?
- Animal Movement
- Personnel
- Manure/Litter/Bedding Management
- Feed/Water
- Wildlife/Rodent/Animal Control
- Carcass Disposal
What is Coccidioidomycosis or Valley Fever?
- Inhalation of fungal spores
- Dogs mostly, but variety of animals can acquire
- Vaccine modified live gene deleted fungal vaccine q 6 months
- Avoid high dust areas
- Symptoms - coughing, fever, weight loss, swollen testicles, lack of appetite, lack of energy, ocular inflammation, severe joint pain, seizure, increased LN
What is Q Fever?
Agent: Coxiella Burnettii (bacteria)
Species: Goats, Sheep, Cattle, Other Mammals, Birds and Reptiles
Tissues: Feces, urine, milk or birthing fluids (can also be spread by ticks)
Illness: fever, pneumonia, muscle pain, abortions, still births
Humans: < 50% of infected humans become ill and it is the second most common laboratory infection
What is Epizootic Hemorrhagic Disease Virus?
Genus: Orbivirus
Family: Reoviridae
Related to Bluetongue virus
Effects: White-tailed deer (cattle usually subclinical or mild and may still get oral ulcers)
Vector: Culicoides Midges (Prevention is control of this)
5-10 year cycle
Develop Signs in 7 days (anorexia, extreme fever, lose fear of people, blue tongue, excessive salivation (Peracute, acute and chronic forms)
Is Glanders Reportable to WOAH?
Yes Burkholderia mallii (but not Melioidosis - pseudomallii)
What type of virus is chikungunya?
Togavirus (Alphavirus)
Does pseudorabies cause neurologic signs in pigs?
No (Nipah virus does)
What is Seoul Virus?
Hantavirus (Bunyaviridae) - symptoms range from mild flu to renal failure (Carried by Brown Norway Rats)
What is African Horse Sickness?
Genus: Orbivirus
Family: Reoviridae
Effected: Horses and Occasionally dogs from eating horse meat
Arthropod borne (culicoides, mosquitoes and ticks)
Often Fatal in Horses & Mules (Zebras and African Donkeys more resistant, possible reservoirs)
Respiratory disease, cardiac disease or cyclic fever forms (fever may recover)
60 day quarantine coming from countries with it
Control: Vector control, MLV (Subunit)
What is Monkey Pox?
Genus: Orthopoxvirus
Family: Poxviridae
Vast majority of cases - no travel link
Virus in lesions, body fluids, bedding
Incubation 6-13 days (can be as long as 21 days)
2 Clades - West African - 1% Fatal & Congo Basin -10% Fatal
Smallpox vaccine is cross protective & antivirals
Where did Monkey Pox in the 2003 outbreak come from?
Pet prairie dogs - housed near imported rodents from Gahana (Gambian Giant Rats)
Agencies Involved: USDA, CDC, PHD (Lab testing, vaccine, treatment)
Embargo and prohibition of importation, interstate movement/sale and release into the environment of certain rodent species
FDA resended
What is African Swine Fever?
Only DNA arbovirus
Genus: Asfivirus
Family: Asfavirus
Orthinodoros are the only arthropod hosts
How is ASF transmitted?
Direct, Indirect, Tick Vector
What are ASF viral sources?
Blood, tissues, secretions of sick/dead
Which animals are carriers of ASF?
Warthogs, Bush pigs or pigs that have recovered from the acute or chronic form
What are the forms of ASF?
1) Peracute - sudden death
2) Acute - highly virulent
3) Subacute - moderately virulent
4) Chronic - moderate to low virulence
Can you differentiate ASF from CSF?
No
Ddx: PRRS, Erysipelas, Salmonella, Pseudorabies and other septic diseases
How do you test for ASF?
Agent identification and Serology
How do you remember the viruses in the family paramyxovirdae (slime beyond slime)?
Negative strand RNA, enveloped
They cause HARRM
Henipa (Hendra, Nipah)
Avula (Avian Paramyxovirdae)
Rubula (Measles, Mumps, Human Paraflu)
Respiro (Bovine, Porcine, Human Paraflu)
Morbilli (Rinderpest, Distemper, Phocine, Measles, Peste de pestis ruminant)
Teratogenic Viruses Change US
Bluetongue, Ibaraki (Reovirus Family) - Culicoides vector
Akabane, Schmallenberg (Bunyaviridae) - Culicoides vector
BVD - Flavivirus Family-Direct Transmission
Picorna viruses are A maize ING
Small, nonenveloped rna viruses
Transmission is fecal-oral except rhinoviruses
Poliovirus is in this group
Veterinary Picornaviruses (HATS)
Hepato: Hepatitis A
Aphtho: Bovine rhinitis, Equine rhinitis, FMD
Tescho: Porcine enterovirus
Seneca: Seneca Valley Virus (looks like FMD)
What are the 5 Families of Viral Hemorrhagic Fevers?
FATAL FEVERS ARE A BIG PAIN
- Filoviridae - Ebola, Marburg
- Flaviviridae - Dengue, Yellow Fever, Omsk Fever, West Nile, Kyasanur Forrest Disease
- Arenaviridae - Lassa, Junin Virus, Machupo, Sabia, Guanarito
- Bunyaviridae - (All Vectored Except HANTA) - Hantavirus, Rift Valley Fever, Crimean Congo Hemorrhagic Fever
- Paramyxoviridae - Measles, Mumps, Distemper, Rinderpest, New Castle, Henipaviruses
Flaviviruses (family) are what type of viruses?
Positive, Single-stranded, enveloped RNA, arboviruses (vectored by mosquito or tick)
What are the Encephalitis Syndromes caused by Flaviviruses?
Mosquito Vectored - St. Louis, Japanese, West Nile
Tick Vectored - Kyasanur Forrest Disease, Powassan, Louping Ill
What are the Rash/Arthralgia Diseases caused by Flaviviruses?
Mosquito Vectored - Dengue, Zika
What are the Hemorrhagic Diseases caused by Flaviruses?
Mosquito Vectored - Dengue, Yellow Fever
Tick or Rodent Vectored - Omsk Hemorrhagic Fever
What are the 3 viral families that cause Encephalitis?
Toga, Flavi and Bunya
What are the Toga viruses that cause encephalitis?
Chikungunya, EEE, WEE, VEE, Ross River Virus
What are the Flavi viruses that cause encephalitis?
St Louis, West Nile, Powassan, Kyasanur Forrest, Japanese
What are the Bunya viruses that cause encephalitis?
Crimean Congo Hemorrhagic Fever, Rift Valley, La Crosse, Hantavirus
What are the major diseases in the Reovirus Family in the Genus Orbivirus vectored by culicoides (non-zoonotic and can be FATAL)?
Blue Tongue
African Horse Sickness
Epizootic Hemorrhagic Fever
(Double Stranded DNA Viruses)
What are the characteristics of Blue Tongue?
Species: Sheep, Cattle, Deer
Symptoms: May be asymptomatic +/- abortion or severe with hemorrhage and edema
What are the characteristics of African Horse Sickness?
Species: Equids
Symptoms: Paracute lung or Subacute cardiac
What are the characteristics of Epizootic Hemorrhagic Fever?
Species: Cervids in N. America/Ibaraki Disease - same subgroup cattle (resembles blue tongue)
Symptoms: Peracute death, chronic disease (Cattle may be subclinical)
What type of virus is Classical Swine Fever?
Genus: Pestivirus
Family: Flaviviridae
Enveloped RNA
What are the forms of CSF?
Acute, Chronic, Congenital, Mild (100% Fatal)
True or False: If exposure to CSF happens prenatal, persistent infection is likely.
True
What are the ways CSF is transmitted?
Direct, Indirect, Aerosol or Wild Boar