Infectious Disease Committee Flashcards
Men B Vaccine: what type of vaccine is it and who gets it?
It is a conjugate vaccine because the polysaccharide does not make a good response.
You are at risk for Men B if you are immunocompromised, you have asplenia, functional asplenia, complement deficiency or eculizimab (anti-complement)
Need 2-3 doses q 8 weeks.
If you receive it prior to 12 months then Booster q 3-5 years until 7 and then every 5 years after that.
Rotavirus: Who is it contraindicated in and when is it given?
Given: 1st dose prior to 15 weeks; 2nd dose prior to 8 months
CI: Immunocompromised (live vaccine); previous history of intussuseption, anaphylaxis to any of the components.
AOM: Statement pertains to what age?
Who is it safe to watch and wait? Who gets immediate antibiotics?
Length of Treatment
> 6 months of age. If there is perforation and purulent drainage, it is more likely to be a bacterial infection.
Immediately treat: Fever >39; Severe pain; moderate to severe unwell; Ill >48 hours
Length:
<2 years: 10 days
>2 years: 5 days
Complications of AOM
Meningitis Mastoiditis 6th nerve palsy Sinus venous thrombosis Facial Nerve Palsy
Palivuzumab - who qualifies? When is RSV Season
Season: November - March
Qualifying Children:
1. <1 years of age with CLD requiring ongoing therapy
2. <1 years of age with hemodynamically significant cardiac disease
3. Born at <31 weeks and are <6 months at the start of the season
Consider if:
- Born <36 weeks and live in remote area
- Inuit children <6 months of age
- <24 months and high risk congenital syndrome or immunocompromised.
Opthalmia neonatorium
What to do if mom is N. gonorrhea + or unknown.
All pregnant women should be screened for chlamydia and gonorrhea. If women are at risk, they should be screened in their third trimester or at delivery if they aren’t during 3rd.
N. Gonorrhea:
If mom’s status is unknown, she should be tested at the time of delivery. Tell about risks - baby looking unwell, eye crusting.
If unsure if parent will be compliant, then treat with IM Ceftriaxone (baby) prior to discharge
If mom POSITIVE (vaginal delivery or c/s) and untreated:
Baby needs to be treated right away and also have a swab. If the baby is unwell in anyway then they have the full work up including CSF.
Chlamydia: no routine cultures
Asplenia: What are they at risk for developing?
PC SHiNE SKiS Pneumococcus crypto Strep Pneumo Hib Neisseriea Ecoli Salmonella Klebsiella GBS
Asplenia Prophylaxis
0-3 months of age: Clavulin or amoxicillin
3-5 years: Pen V or Amoxicillin
Can be life long, but at least needs to be 2 years post splenecomty and up to 5 years if asplenic secondary to sickle or other disease.
HSV In pregnancy
The most common time for aquisition of disease is intrapartum (can be up to 75% chance of acquiring).
Scenarios of mom’s with HSV and treatment process:
Primary Infection (HSV 1 or 2): Biggest risk factor
- C/S AFTER rupture: MM swab at 24 hours (can NOT do before due to false negative) and initiate acyclovir. Await mom serologies. If Positive baby needs full work up including LP
- C/S no ruptuer: MM swab >24 hours
First episode but non primary (history of another type of HSV): Treat as if primary infection
Recurrent (will pass on to baby): mm swab >24 hours.
HSV infections in newborn infants
Localized/ Skin Eyes and Mucous Membranes: 14 days
Disseminated: 21 days
CNS: 21 days at least and need repeat LP
Needle Stick Injuries in Community
Risk of obtaining Hep B, Hep C and HIV
Management: Always clean the wound first with soap and water and do NOT squeeze out blood.
Determine vaccination status of Tetanus and Hep B.
Testing for HIV, Hep B and Hep C baseline. Do not require testing of the needle, as likely to be negative, but does not mean it is actually negative.
Hep B:
Known immune: no further treatment
Not fully immunized: Test HbAb and HbAg - if not available in 48 hours give HBIG and vaccine
If Fully vaccinated: Still test, because if HbAb negative, but HbAg + then they are infected and need further follow up.
HIV: If high risk and think you need prophylaxis, it is best to start within 1-4 hours (MAX would be 72 hours later).
Medium risk: 2 meds
High risk: 3 meds
Duration: 28 days.
Recheck antibody at 6 weeks, 3 months and 6 months.
HCV: no prophyalxis, check Hep C antibody at time of injury, 3 months and 6 months.
Treatment of Uncomplicated Pneumonia
Non Severe: Amoxicillin
Non Severe + atypical features: Clarithro or azithro
Severe: Cefriaxone + macrolide
Pneumatocele present - vancomycin
Treatment: 7-10 days
Lyme Disease: Stages of Disease
There are three stages to disease.
Stage 1: Classic Targetoid lesion rash. Patient is otherwise assymptomatic, and this will usually resolve by about 4 weeks.
Stage 2: Early disseminated disease: Migratory rash and nerve palsies
Stage 3: Big joint arthritis
Jarish Herxhemier reaction
When you first start treatment and you have fever, headache, myalgias
Treatment for Lyme Disease
Doxycycline (in children >8 years of age)
Amoxicillin
Cefuroxime
IV: Ceftriaxone