Infectious Disease

Question 1

3 late complications of GAS

Answer 1

1- Scarlet fever
2- Rheumatic fever
3- Post-streptococcal GN

Question 2

Pathophysiology of Rheumatic fever

Answer 2

Inflammatory disease due to cross-reactivity following GAS infection

Question 3

What are the clinical diagnosis criteria for rheumatic fever?

Answer 3

Jones Criteria:
2 major OR 1 major and 2 minor + evidence of preceding Strep infection:

• Major: Carditis and valvulitis, arthritis, CNS involvement, subcutaneous nodules, erythema marginatum
• Minor: Arthralgia, fever, increased ESR or CRP, prolonged PR interval