Infectious Agents Flashcards

1
Q

What are common symptoms of meningitis?

A
  • HA
  • Neck Stiffness
  • Fever
  • Photophobia
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the most common causes of viral meningitis?

A
  • Coxsackie Virus
  • Echovirus
  • Arbovirus (Mosquito)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

If a healthy 34 year old male presents to the ED with a headache with a fever and CT reveals a well-circumscribed lesion, what might be the infectious agent responsible?

A
    • Staph Aureas

- - Strep

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are characteristic findings of brain abscesses to have a confirmatory diagnosis?

A
    • Well-circumscribed lesion with central necrosis
    • Fibrotic Wall of collagen
    • Numerous PMNs surrounding
    • “Ring Enhancement Lesion” on imaging
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What might be the CSF findings of TB-associated meningoencephalitis?

A
    • Elevated Lymphocytes

- - Low Blood Glucose

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What are unique characteristics of TB-meningoencephalitis?

A
    • Enhancement of the base of brain on MRI + vasculitis
    • Tuberculoma - mass lesion w/ central caseous necrosis with Epithelial Histiocytes / Giant Cells
    • Pott’s Disease - granulomatous process of vertebral bodies leading to cord compression
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What chronic infection is manifests with general paresis, meningovascular meningitis, and tabes dorsalis?

A

Treponema Pallidum

    • gradual cognitive impairment
    • chronic multifocal arteritis–infarctions-thickening of vessels walls until occulsion
  • -Lightning pains, loss of positional-vibrational senses
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

If on an after death autopsy you unconver perivascular lymphocytic infiltrates, microglial nodules, and neuronophagia; what might have been a pathologic process occurring at the time of death?

A

Viral Encephalitis

–Those symptoms are consistant with general viral encephalitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

A 27 year old female presents to the emergency department with abnormal behavior according to friends and erratic moods complaining of a headache several days ago. What might be found on MRI scan?

A

HSV1 Most Likely

  • Focal abnormalities of the Temporal Lobes
  • Hemorrhagic inflammatory necrosis / swelling
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

If a biopsy what taken of an individual thought to have Herpes Simplex encephalitis what might they find?

A
  • Intranuclear inclusion bodies

- Cowdry Type A Cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Contrast the patient populations who acquire HSV1 and HSV2 encephalitis?

A

HSV1 – General Population

HSV2 – Neonates who acquire HSV2 from active infection in the mother during birth.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

How is Arbovirus acquired and when should you be suspicious of Arbovirus?

A

Mosquitos – Season, most common during the summer.

Epidemic Encephalitis – when several people in the community contract it.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What virus most common affects Microglial cells?

A

HIV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What are the symptoms associated with chronic HIV infection?

A

Infect Microglial Cells

    • develop HIV Encephalitis over time (years)
    • Cognitive/Behavioral deterioration
    • Ataxia / Tremor
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What histologic findings is consistent with HIV encephalitis?

A

Microglia Nodule with Multinucleated microglial cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What conditional affects the oligodendrocytes?

A

Progressive Multifocal Leukoencepholopahty

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What is responsible for Progressive Multifocal Leukoencephalopathy?

A

Reactivation of JC Virus

– Immunocompromised individuals

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

How does Progressive Multifocal Leukoencephalopathy affect the brain?

A
    • Affects white matter
    • numerous irregular small focal areas of demyelination of the white matter
    • oligodendrocyte inclusions
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What might you find with Apergillus / Mucor encephalitis?

A

– Vasculitis causing small localized hemorrhage infarcts

if Aspergillus – vessels infiltrated with hyphae

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Where does Cryptococcosus come from and how does it end up infecting the brain?

A

Immunocompromised individuals

    • Bird Poop
    • Infects the lungs first, then hemagenously spreads to the brain cauing encephalitis/abscesses
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What are histologic findings with Cryptococcus?

A
    • Thickening of the Meninges from chronic inflammation
    • Intraparenchymal cysts – “Soap Bubbles”
    • Yeast form of fungi
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

If you become infected with Toxoplasma what might the pathologic findings be?

A
  • Very small areas of necrosis throughout the brain

- Organisms free in tissue in pseudocysts

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

What are the common causes of Epidural / Subdural empyemas?

A

Hematagenous spread from ENT infection

    • Strep
    • Staph
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

What is the common clinical presentation of Prion Disease?

A

Rapid progression of dementia, ataxia, myoclonic jerking
– EEG = triphasic waves 1-2s
– MRI = increased signal in basal ganglia
Symptom onset progression in months, death within a year.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
What are the most common causes of Prion Disease?
- Idiopathic -- Creutzfeld-Jakob Disease (50%) - Inherited (15%) - Acquired from Surgery - Eating Cow w/ Mad Cow
26
What is the mechanism of action of the abnormal proteins in Prion Disease?
- Abnormal PrPsc infiltrates the body and is able to interact with normal PrPc proteins changing them into abnormal versions - PrPsc do not degrade normally and aggregate in the brain causing the symptoms
27
What is the most common cause of meningitis?
Strep Pneumoniae
28
What is the most common types of meningitis in children less than 1 year old?
Neisseria Meningitidis | Group B Strep
29
What is commonly found in adults over the age of 50 and/or immunocompromised?
Listeria Meningitis
30
What types of bacteria can cause meningitis after surgery or neurosurgery?
Skin Bacteria - Strep Agalactiae - Staph Epidermis
31
What might be the causative agent in an individual with meningitis symptoms progressive over several weeks?
Cryptococcus -- immune compromised
32
What causative agent might be at fault for development of meningitis during the summer months?
- - Enterovirus | - - Arbovirus / Borrelia Burgdorfi / Ricketti -- Mosquitos
33
What is the most common etiology of meningitis of a 2 year old who lives in a closed community?
-- Haemophilus Influenza
34
What are the differences in CSF findings when evaluating for meningitis?
Bacteria -- Elevated PMNs, Low Glucose Viral -- Elevated Lymphocytes, Normal Glucose Fungi -- Elevated Lymphocytes, Low Glucose
35
What should be started as empiric therapy for a 57 year old male with negative gram staining CSF?
- Ceftriaxone - Vancomycin - Corticostertiods - Ampicillin -- only if gram negative and 50+ (Listeria)
36
What are the two most common causes of meningitis?
- Strep Pneumoniae - everyone | - Neisseria Meningitis -- under 1 and 16-21 year olds
37
What is the most common means of acquiring meningitis from strep pneumoniae?
-- Pneumonia first, then has hemagenous spread into the blood brain barrier -- Meningitis
38
What serotype is not protected with the Neisseria conjugate vaccine?
Serotype B -- due to reactivate to human self-antigens
39
Who are most suspectible to Haemophilus Influenza meningitis?
Between the ages of 3 months and 3 years
40
What is the the capsule made from of the most virulent strain of Haemophilus?
Ribose / Ribitol -- Type B
41
Why is an infant not suspectible to Haemophilus immediately after birth?
-- due to maternal antibodies circulating for up to 3 months
42
What are the characteristics of Haemophilus?
- gram negative | - small coccibacilli
43
What does the Haemophilus vaccine consist of and how does it prevent infection?
- PRP-D + Diptheria (Conjugate Vaccine) | - Induces a T-cell dependent response producing Memory T-cells
44
If a CSF sample gram stains positive with diplococci, what might be the organism?
Strep Pneumoniae
45
What are the virulence factors of Neisseria?
- Lipooligosacchride - Polysacchride Capsule - Fimbriae - attachment
46
How does Neisseria go about causing meningitis?
-- Fimbriae attaches in the Nasopharynx, then Lipooligosacchride induce immune response and it can slip into the blood-brain barrier
47
Who are the patient populations most susceptible to Neisseria infections?
- Under 1 year old - 16 - 21 years old attending college-close quarters - Asplenic individuals
48
What patient population is recommended to get the MCV4 vaccine?
MCV4 --- Neisseria Conjugate Vaccine | -- Anyone under the age of 55
49
How is the MPSV4 Vaccine different from the MCV4?
MCV4 - Conjugated Vaccine MPSV4 -- Polysacchride Non-conjucated -- Used for 55+ individuals expanded coverage of strains of Neisseria
50
How is the Neisseria presentation unique in meningitis?
- Very Rapid Progression of symptoms and demise after infiltrating the CNS
51
What extra precaution should be taken when dealing with Neissera?
-- Any contact with the patient should receive prophylaxis Antibiotics
52
What are the characteristics of Strep Pneumoniae?
- Gram Positive diplococci | - Alpha-hemalytic
53
What other regions does Strep Pneumoniae infect besides the CNS?
- Otitis Media - Pneumonia - Pharyngitis - Sinusitis
54
When might you give the PPSV23 vaccine to a patient?
After they turn 65 for an expanded spectrum of protection from strep pneumoniae -- polysacchride vaccine
55
What is the PCV13 vaccine used for?
Conjugate Vaccine against Strep Pneumoniae | -- Given to Everyone
56
What patient population might Strep agalactiae meningitis be found in?
- - Neonates / Preterm Infants | - - Bacteria resides in the mothers vagina and can infect the baby as being delivered.
57
You can prevent Strep Group B from infecting a neonate on delivery?
- - Prophylaxis can be given to the mother if she previously had a child infected - - Penicillin
58
Is there a vaccine for Strep Agalactiae? What is the treatment?
No there is no vaccine. | -- Treat with Penicillin
59
What are the characteristics of Rabies virus?
- Rhabdovirus / Rod Bullet shaped - (-)ssRNA - Can bind ACh receptors throughout the body getting into the PNS
60
When the rabies virus is replicating, does it cause the host cell to die?
- No.
61
How does the rabies virus go about infecting the CNS?
- enters through an abrasion / bite in the skin / transplant - variable latent period - enters PNS carried into the CNS - once into CNS rapid replication, then spread distally
62
What are the tissues most common associated with rabies infection?
- Eyes - Salivary Glands - Hair Follicles
63
What site of infection would cause a more rapid progression of rabies disease? - - Ankle Bite - - Abdominal Scratch
Abdominal Scratch with rabies infected animal, closer to the CNS. -- further away the longer it takes
64
What are the initial symptoms of a rabies infection?
- Nervousness - Anxiety - HA / Fever/ Nausea
65
What are the end-stage symptoms of Rabies?
- Crazed Behavior / Aggressive - Hydrophobia - Flaccid Paralysis
66
How can you diagnose an individual with Rabies?
- - Most commonly focal neurologic symptom with a history with possible exposure - - Sometimes: Negri Bodies / Direct Flourescence Antibodies
67
What is the most common exposure to Rabies in North America?
- Bats / Rabid Wild Animals
68
What is the post-exposure prophylaxis when exposed to Rabies? Is it time sensitive?
- - Give Passive Immunization HRIG/ERIG (immunoglobin) in order to prevent the spread of the virus from its localized infection point - - Begin Vaccine at the same time x4 doses - - Somewhat time sensitive, but sooner rather than later