Headaches Flashcards

1
Q

What are “red flag signs” that warrant more thorough evaluation of headache?

A
  • first / WORST headache
  • SUDDEN ONSET
  • CHANGE in pattern or intensity of headache
  • hx of cancer or HIV
  • associated neuro symptoms (seizure, syncope, etc)
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2
Q

When would a CT/MRI scan be warranted for a patient who has chronic migraine headaches?

A
  • Change in headache pattern of onset
  • new onset seizures
  • focal neurologic symptoms
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3
Q

If a patient gets a supraorbital unilateral headache every week that last for an hour or two with associated watering of the eyes, what classification is that?

A
  • Cluster Headache
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4
Q

What are the general characteristics of a cluster headache?

A
  • Short lasting 15-180minutes
  • unilateral (temporal, supraorbital, orbital)
    + Associated Parasympathetic Symptoms
    – lacrimation, rhinorrhea, miosis, ptosis, etc
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5
Q

What can sometimes be associated with a cluster headache?

A

Horner Syndrome – loss of sympathetic input

  • ptosis
  • miosis
  • lacrimation
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6
Q

What are the criteria for Migraine without an aura?

A

Must have at least 5x episodes with these characteristics
- lasting 4-72 hours
- unilateral location - pulsating
- intensity prohibits daily activities
- aggravated by movement
+++ Associated with: (at least one)
– Nausea / Vomiting / Photophobia / Phonophobia

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7
Q

What are the best predictors of migraine headaches?

A
  • Nauea
  • Disability
  • Photophobia
    • if 2/3, then there is a 96% chance of migraine diagnosis
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8
Q

How do you diagnosis a tension headache?

A
15 days per month x 3 months
- fluctuating length of time
- nonpulsating - mild/moderate intensity
- bilateral location
- doesn't change with movement 
\+++ Associated with: Only 1 
-- Photophobia/Phonophobia
-- Mild Nausea (not severe)
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9
Q

What are other manifestations of tension headache?

A
  • Neck pain

- Back pain

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10
Q

What is a common reason believe they have a “sinus headache” (doesn’t exist)

A
  • location
  • weather as trigger
  • improves with sinus medication
    (that’s only because ephedrin causes constriction of vessels, which can improve headaches)
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11
Q

What are risk factors for chronic daily headaches that are modifiable?

A
  • obesity
  • medication overuse
  • stressful life
  • snoring
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12
Q

What are risk identifiers for daily headaches, nonmodifiable?

A
  • Females
  • Low education
  • Low socioeconomic status
  • Hx Head injuries
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13
Q

What the general pathology that causes headaches?

A
  • Enhanced release of excritatory neurotransmitters
  • Reduced amount of inhibition
  • Low Mg+2
  • Altered energy metabolism in brain
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14
Q

What are the timeline of events that lead to a headache?

A
  • Wave of intense cortical activity
  • Followed by a wave of neuronal suppression
  • Wave of activity moves 2-3mm/min
  • if begins in a occiptial silent area, then no aura, if working area, then aura develops first.
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15
Q

What are physiology associated with a development of a headache?

A
  • influx of excitatory neurotransmitters - Glutamate
  • migratory activity, followed by an increased Archadonic Acid and NO for increased blood flow due to activation of the trigeminovascular system
  • Decreased descending inhibition of pain during migrate
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16
Q

What amino acid is required to produce Serotonin?

A

Tryptophan

17
Q

What breaks down Serotonin and what deactivates it from the clefts?

A

SERT – deactivates from cleft w/ reuptake

MAO - breaks down

18
Q

Where are the serotonnergic neurons located in the brain?

A
  • Raphe Nucleus
19
Q

What are the major class of drugs used to abort migraine headaches?

A
  • Triptans
    • Serotonin Receptor 1B/1D Agonists
    • Promotes Vasoconstriction
20
Q

What are the major mechanisms of how Triptans work?

A
  • Inhibit release of vasoactive peptides
  • Promote vasoconstriction
  • Block brainstem pain pathways
  • Inhibits the trigeminal nucleus caudalis
    (responsible for the vasodilation)
21
Q

How is the HT1B receptor responsible for the action of the Triptan?

A
  • G-protein coupled

- Induces these changes by activating in the neuron

22
Q

What are common side effects of Triptans?

A
  • peripheral vasoconstriction
  • Angina
  • Dizziness/Flushing
23
Q

Who should Triptans NOT be given to?

A
  • Recent Stroke or MI

- Uncontrolled HTN

24
Q

What is a 2nd line therapy for abortive migraine therapy?

A

Ergots – 1A Receptor Agonist

25
Q

What are other methods for aborting migraines?

A
  • NSAIDs with Caffeine
  • Steroids
  • Butalbital/Caffeine/Acetaminophen – easily abused
26
Q

What can be used to prevent migraine headaches?

A
Tricyclic Antidepressants - used for chronic pain
- Amitryptyline / Nortriptyline
Antiseizure Agents
- Divalproex Sodium / Valproic Acid
- Topiramate