Infections in immunodeficiency

Question 1

Infections without T cells

Answer 1

Bacterial - sepsis

Viral - CMV, EBV, JCV, VZV

Fungi/parasites - Candida, PCP

Question 2

Infections without B cells

Answer 2

Bacterial - encapsulated bacteria (S. pneumoniae, H. influenzae type B, N. meningitidis, E. coli, Salmonella, Klebsiella pneaumoniae, Strep)

Viral - Enteroviral encephalitis, poliovirus (do not give live poliovaccine)

Fungi/parasites - GI giardiasis (no IgA)

Question 3

Encapsulated bacteria

Answer 3

“SHiNE SKis”:

• S. pneumoniae
• H. influenzae type B
• N. meningitidis
• E. coli,
• Salmonella
• Klebsiella pneumoniae
• Strep

Question 4

Infections without granulocytes

Answer 4

Bacterial - Staph, Burkholderia cepacia, Serratia, Nocardia

Viral - N/A

Fungi/parasites - Candida (hematogenous spread), Aspergillus

Question 5

Infections without complement

Answer 5

Bacteria: Neisseria (no membrane attack complex)

Virus: N/A

Fungi/parasites: N/A