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Immunology > Autoantibodies > Flashcards

Autoantibodies Flashcards

1
Q

Anti-ACh receptor

A

Myasthenia gravis

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2
Q

Anti-basement membrane

A

Goodpasture syndrome

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3
Q

Anti-cardiolipin, lupus anticoagulant

A

SLE, antiphospholipid syndrome

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4
Q

Anti-centromere

A

Limited scleroderma (CREST syndrome)

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5
Q

Anti-desmoglein

A

Pemphigus vulgarism ( + Nikolsky sign, unlike bullous pemphigoid)

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6
Q

Anti-dsDNA, anti-Smith

A

SLE

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7
Q

Anti-glutamate decardboxylase

A

Type 1 diabetes mellitus

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8
Q

Anti-hemidesmosome

A

Bullous pemphigoid ( - Nikolsky sign, unlike pemphigus vulgaris)

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9
Q

Anti-histone

A

Drug-induced lupus (Sulfa drugs, Hydralazine, INH, Procainamide, Phenytoin, Etanercept)

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10
Q

Anti-Jo-1, anti-SRP, anti-Mi-2

A

Polymyositis

Dermatomyositis

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11
Q

Anti-microsomal, anti-thyroglobulin

A

Hashimoto thyroiditis

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12
Q

Anti-mitochrondrial

A

Primary biliary cirrhosis (women>males)

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13
Q

Anti-nuclear antibodies

A

SLE, nonspecific

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14
Q

Anti-Scl-70 (anti-DNA topoisomerase I)

A

Scleroderma (diffuse)

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15
Q

Anti-smooth muscle

A

Autoimmune hepatitis

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16
Q

Anti-SSA, anti-SSB (anti-Ro, anti-La)

A

Sjogren syndrome

17
Q

Anti-TSH receptor

A

Graves disease

18
Q

Anti-UI RNP (ribonucleoprotein)

A

Mixed connective tissue disease

19
Q

c-ANCA (PR3-ANCA)

A

(Wegener) Granulomatosis with polyangitis

20
Q

p-ANCA (MPO-ANCA)

A

Microscopic polyangitis
Churg-Strauss syndrome
Ulcerative colitis
Primary sclerosing cholangitis (male>female)

21
Q

IgA anti-endomysial, IgA anti-tissue transglutaminase, IgA anti-gliadin

A

Celiac disease; look for IgG antibodies in individuals with IgA deficiency (higher incidence in patients with Celiac disease)

22
Q

Rheumatoid factor (IgM specific to IgG Fc region), anti-CCP

A

Rheumatoid arthritis

Immunology (5 decks)

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