Autoantibodies Flashcards
Anti-ACh receptor
Myasthenia gravis
Anti-basement membrane
Goodpasture syndrome
Anti-cardiolipin, lupus anticoagulant
SLE, antiphospholipid syndrome
Anti-centromere
Limited scleroderma (CREST syndrome)
Anti-desmoglein
Pemphigus vulgarism ( + Nikolsky sign, unlike bullous pemphigoid)
Anti-dsDNA, anti-Smith
SLE
Anti-glutamate decardboxylase
Type 1 diabetes mellitus
Anti-hemidesmosome
Bullous pemphigoid ( - Nikolsky sign, unlike pemphigus vulgaris)
Anti-histone
Drug-induced lupus (Sulfa drugs, Hydralazine, INH, Procainamide, Phenytoin, Etanercept)
Anti-Jo-1, anti-SRP, anti-Mi-2
Polymyositis
Dermatomyositis
Anti-microsomal, anti-thyroglobulin
Hashimoto thyroiditis
Anti-mitochrondrial
Primary biliary cirrhosis (women>males)
Anti-nuclear antibodies
SLE, nonspecific
Anti-Scl-70 (anti-DNA topoisomerase I)
Scleroderma (diffuse)
Anti-smooth muscle
Autoimmune hepatitis
Anti-SSA, anti-SSB (anti-Ro, anti-La)
Sjogren syndrome
Anti-TSH receptor
Graves disease
Anti-UI RNP (ribonucleoprotein)
Mixed connective tissue disease
c-ANCA (PR3-ANCA)
(Wegener) Granulomatosis with polyangitis
p-ANCA (MPO-ANCA)
Microscopic polyangitis
Churg-Strauss syndrome
Ulcerative colitis
Primary sclerosing cholangitis (male>female)
IgA anti-endomysial, IgA anti-tissue transglutaminase, IgA anti-gliadin
Celiac disease; look for IgG antibodies in individuals with IgA deficiency (higher incidence in patients with Celiac disease)
Rheumatoid factor (IgM specific to IgG Fc region), anti-CCP
Rheumatoid arthritis
