infections during pregnancy and childbirth

Question 1

what is 1st line treatment for UTI in pregnancy?

Answer 1

nitrofurantoin 50mg 4x per day or 100mg modified release 2x per day for 7 days

Question 2

what is the 2nd line treatment for UTI in pregnancy?

Answer 2

cephalexin oral 500mg 2x per day for 7 days

or

amoxicillin 500mg 3x per day for 7 days if sensitive

Question 3

what are the complications of asymptomatic bacteriuria in pregnancy?

Answer 3

increased risk of pyelonephritis and preterm delivery

Question 4

what are possible complications of chorioamnionitis?

Answer 4

neonatal cerebral palsy

Question 5

what is the treatment for chorioamnionitis?

Answer 5

IV antibiotics + delivery via c-section

Question 6

what puts a woman at risk of chorioamnionitis?

Answer 6

premature rupture of membranes

risk factors for PROM;

• low BMI
• previous PROM
• smoking
• STI
• polyhydramnios

Question 7

what is the presentation of chorioamnionitis?

Answer 7

fever

raised neutrophils

Question 8

what is the pathophysiology of chorioamnionitis?

Answer 8

ascending bacterial infection of the membranes / placenta / amniotic fluid

premature rupture of membranes exposes the sterile environment of the uterus to potential pathogens
however can occur in absence of PROM