Infections

Question 1

Examples of non-sexually transmitted reproductive tract infections?

Answer 1

Vulvovaginal candidiasis - fungal, candida likely

Bacterial vaginosis

Post-partum sepsis - fever, discharge, rigors

Toxic shock syndrome: due to staph-aureus colonising tampon if left in too long

Prostatitis: acute or chronic

Question 2

Two types of sexually or non-sexually transmitted infections of the reproductive tract?

Answer 2

Epididymo-orchitis: acute bacterial infection of the epididymis

Pelvic inflammatory disease

Question 3

STI examples?

Answer 3

Gonorrhoea - Males more symptomatic

Chlamydia

Non-specific urethritis

Trichomonasis

Syphilis

Herpes

Question 4

Process of HIV infection in T helper cells?

Answer 4

Gp120 binds to CD4 antigen

Gp41 causes fusion and entrance of the virus

Question 5

What are chemokine co-receptors and how are they involved in HIV infection?

Answer 5

HIV enters the cell through these co-receptors two types: CCR5 and CXCR4

Question 6

HIV treatment?

Answer 6

ART - antiretroviral treatment, does not cure but will suppress

Question 7

ART S/Es?

Answer 7

Mitochondrial dysfunction - lactic acidosis

Metabolic abnormalities - fat maldistribution, hyperglycaemia, Insulin sensitivity

Bone marrow suppression - anaemia, neutropenia,