Infection Summary Flashcards
Gastroenteritis Presentation
vomiting and diarrhoea (3 or more loose stools a day), + abdominal pain/discomfort (can be quite severe if campylobacter), fever,
bloods in stool can be indicative of a bacterial infection
signs of dehydration:
thirsty, dry mucous membranes: mild, (<5% weight loss)
lethargic, reduced skin turgor, sunken eyes, sunken anterior fontanelle, tachycardia, reduced urine output, reduced tears: moderate (5-10% weight loss)
drowsy, absent urine output, prolonged capillary refill time, weak pulse, low BP (signs of hypovolaemic shock): severe (>10% weight loss)
Gastroenteritis Investigation / diagnosis
stool MC&S, urea and electrolytes
Gastroenteritis Management
oral rehydration therapy given frequently in small amounts; IV fluids if not tolerating oral/nasogastric fluids. Good handwashing to prevent spread. Notify public health if bacterial
Complications of campylobacter infection
Guillain-Barre
Reactive arthritis
What can predispose you to gastroenteritis?
HIV
Omeprazole
Presentation of CDIFF
mild diarrhoea to severe colitis
diarrhoea, fever, abdominal pain
Investigations for CDIFF
stools MC&S, FBC (increased WCC)
Treatment for C. Diff
metronidazole (first line), stool transplant, oral vancomycin (second line), fidaxomicin, surgery may be required, isolation, barrier nursing
prevention: stop AB (cephalosporin, clarithromycin, clindamycin, co-amoxiclav)
What are the complications of C.Diff?
pseudomembranous colitis, toxic megacolon, sepsis
What are the toxins that c.diff produces?
A (enterotoxin) and B (cytotoxin)
Presentation of infectious diarrhoea
fever, diarrhoea (may be bloody), nausea, dehydration, abdominal pain, bloody diarrhoea is more common with Campylobacter, Shigella
What is the diagnosis of infectious diarrhoea?
diagnosis by antigen detection
FBC, U&E, CRP, stool microscopy, culture and sensitivity (MC&S), blood cultures if septic
What is the management of infectious diarrhoea?
majority of cases are self-terminating and require rehydration and electrolyte correction: AB are considered in immunocompromised patients, the very young or the very septic; always liaise with microbiologists
What viruses can cause infectious diarrhoea?
adenovirus, rotavirus in children under 5 years
What are the complications of infectous diarrhoea?
renal failure, septic shock; E. coli is associated with the haemolytic-uraemic syndrome
What are the symptoms / presentation for giardia lamblia?
diarrhoea, malabsorption, failure to thrive
What is the investagation for giardia lamblia?
Cysts seen on stool microscopy
What is the treatment for giardia lamblia?
Metronidazole
How is giardia lamblia spread?
Contaminated water
Whet type of organism is giardia lamblia?
Parasite
What bacterium causes the majority of cases of travellers diarrhoea in developing countries?
Enterotoxigenic e.coli
What is the normal reservoir of Ecoli o157 (this is an enterohaemorrhagic bacterium)
2.5% of britich cattle secrete VTEC (verotoxin producing Ecoli)
The reservoir of infectio nis in the gut of herbivores.
The organism has an ectremely low infecting dose.
What are the symptoms of enterohaemorrhagi bacteria?
Initial watery diarrhoea
Becomes blood stained in 70% of cases. Associated with severe and often constant abdominal pain.
Little systemic upset, vomittin or fever.
What is the complication associated with Ecoli o157?
HUS
Haemolytic Uraemic syndrome
Who is affected by HUS?
HUS affects 10-15% of sufferers from this infection
Arises 5-7 days after the onset of symptoms
Most likely i nthe extremes of age, heralded by a high peripheral leucocyte count and may be induced particularly in chgildren by antibiotic therapy
What is the treatment for HUS?
Dialysis if necessary and may be averted by plasma exchange
Antibiotics should be avoided since they can stimulate toxin release.
What cells does the HIV virus attack?
Attacks the CD4 cells (T helper cells, macrophages and dendritic cells)
What are the features of the primary infection of HIV?
Usually symptomatic in more than 50% of cases
Incubation period is 2-4 weeks after exposure
Clinical features resemble a glandular fever type of illness (flu like symptoms - (presence of maculopapular rash and oral ulceration strongly suggests primary HIV infection rather than other viral casues of glandular fever.)
What is the progression of HIV after the primary infection?
Chronic phase which can last 2-10 years.
Depletion of CD4 cells and increase viral load
Clinical latelcy follows primary infection - individuals are asymptomatic.
Persistent lymphadenopathy less than 2cm diameter ius a common finding.
What is the differential diagnosis for primary HIV?
EBV
Primary cytomegalovirus infection
Rubella
Primary toxoplasmosis
Secondary syphilis
When does HIV become AIDS?
The development of specified opportunistic infections cancers and severe manifestations of HIV itself.
Can be diagnosed by having a CD4 count that is less than 200/mm3
CDC is the most used category of AIDS defining illnesses
CDC category A for HIV
Primary HIV infection
Asymptomatic
Persistent generalised lymphadenopathy
CDC category B for HIV
Candidiasis (oropharyngeal)
Fever / diarrhoea lasting for over one month
Oral hairy leucoplakia
Cervial dysplasia / carcinoma in situ
Idiopathic thrombocytopenic purpura
Peripheral neurupathy
CDC category C for HIV infection
Candidiasis of trachea, bronchi or lungs
Cervical carcinoma that is invasive
Cryptococcosis - extrapulmonary
Cytomegalovirus disease (outside the liver spleen and nodes)
Herpes simplex chronic ulcers or visceral
HIV encephalopathy
Kaposi’s sarcoma
Lymphoma (cerebral or B cell non hodgkin)
Pneumocystis pneumonia
Recurrent bacterial pneumonia
Cerebral toxoplasmosis
Tuberculosis
How is viral load determined?
Quantitive PCR of HIV - RNA
How is HIV diagnosed?
By detectiong host antibodies (either by point of care tests or by ELISA)
A positive antibody test from two different immunoasays is sufficiennt to confirm infection
Screening may involve testing for p24 antigen in addition to antibodies (incase antibody production hasn’t started yet)
Nucleic acid amplification (usually PCR) of HIV-RNA is carried out on children who’s mothers have had AIDS (the maternal antibodies will live in their system for 15 months and they might not have produced their own antibodies yet).
What are the aims of ART?
Reduce the viral load to an undetectable level for as long as possible
Improve CD4 count to over 200 cells/mm3 so that severe HIV-related disease is unlikely
Improve the quality of life without unacceptable drug toxicity
Reduce HIV transmission