Infection Processes Flashcards

1
Q

Infection

A

Invasion/colonization of body by pathogenic microorganisms

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2
Q

Disease

A

Occurs when infection results in change from normal state of health

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3
Q

Pathogen

A

Microorganism/virus able to produce disease

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4
Q

Location of portal exit

A

Usually close to organism’s breeding site

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5
Q

Transmission of disease pathway

A

(1) Reservoir
(2) Portal of exit
(3) Mode of transmission
(4) Portal of entry
(5) Susceptible victim

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6
Q

Factors for infection

A

(1) Communicability
(2) Immunogenicity
(3) Pathogenicity
(4) Toxingenicity
(5) Virulence

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7
Q

Risk factors for susceptibility

A
  • nutritional status
  • chronic illness
  • age
  • immunosuppression
  • environment
  • HAI
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8
Q

Breaking the chain of infection

A
  • destroy reservoir
  • block portal of exit/entry
  • block mode of transmission
  • reduce victim’s susceptibility/improve immune system
  • use antimicrobials with caution
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9
Q

Stages of infection

A

(1) incubation period
(2) prodromal stage
(3) invasion/acute illness
(4) convalescence

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10
Q

Classes of infectious microorganisms

A
  • bacteria
  • fungi
  • protozoa
  • virus
  • helminths
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11
Q

Symbiosis

A

benefits only the host not the organism

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12
Q

Mutualism

A

benefits host and microorganism

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13
Q

Commensalism

A

benefits only the microorganism, no harm to host

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14
Q

Pathogenicity

A

benefits the microorganism, harms the host

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15
Q

Opportunism

A

Benign microorganisms become pathogenic due to decreased host resistance or translocation to other body sites

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16
Q

Bacteria characteristics

A
  • cell wall
  • cell shape
  • movement mechanisms
  • gram staining
17
Q

Bacterial virulence factors

A
  • pili
  • flagella
  • capsules
  • enzymes
  • exotoxins
  • endotoxins
  • antibiotic resistance
18
Q

Bacteremia

A

presence of bacteria in the blood

19
Q

Sepsis

A

large amount of infection in the blood

life-threatening

overproduction of pro-inflammatory cytokines

20
Q

Most common bacterial infections

A
  • pneumonia
  • meningitis
  • UTIs
  • TB
  • wound infections
21
Q

Reproduction of fungi

A
  • form spores
  • detach from parent cell
  • germinate into new fungi elsewhere
  • colonize when normal flora are disturbed
22
Q

Mycoses

A

infections caused by fungi

23
Q

Dermatophytes

A

fungi that invade skin, hair, or nails

24
Q

Candida albicans

A

most common cause of fungal infection

opportunistic yeast

25
Q

Subcutaneous fungal infection

A

gets in tissue during trauma

26
Q

Systemic fungal infection

A

inhalation of dust that contains fungus

27
Q

Composition of viruses

A

RNA
- single strand
- single strand retrovirus with reverse transcriptase
- double strand

DNA
- single stranded
- double stranded

Protein shell (capsid)

28
Q

Classification of viruses

A
  • genetic makeup
  • mode of replication
  • structure of viral capsule (capsid)
  • specific host cell that virus invades
29
Q

Viral modes of replication/invasion

A
  • adhere to cell membrane → phagocytosis → capsule opens and releases genetic material inside
  • stick to cell surface and inject genetic material into host
  • manufacture envelope to surround viral capsid and release virus through budding