Infection and Response Flashcards

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1
Q

What are pathogens?

A

Pathogens are microorganisms that cause infectious disease. Pathogens may be viruses, bacteria, protists or fungi. They may infect plants or animals and can be spread by direct contact, by water or by air.

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2
Q

Explain what bacteria and viruses do in the body:

A

Bacteria and viruses may reproduce rapidly inside the body. Bacteria may produce poisons (toxins) that damage tissues and make us feel ill. Viruses live and reproduce inside cells, causing cell damage.

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3
Q

Explain the effects and treatments of Measles?

A

Measles is a viral disease showing symptoms of fever and a red skin rash. Measles is a serious illness that can be fatal if complications arise. For this reason most young children are vaccinated against measles. The measles virus is spread by inhalation of droplets from sneezes and coughs.

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4
Q

Explain the causes, effects and treatments of HIV?

A

HIV initially causes a flu-like illness. Unless successfully controlled with antiretroviral drugs the virus attacks the body’s immune cells. Late stage HIV infection, or AIDS, occurs when the body’s immune system becomes so badly damaged it can no longer deal with other infections or cancers. HIV is spread by sexual contact or exchange of body fluids such as blood which occurs when drug users share needles.

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5
Q

Explain the causes, effects and treatments of Tobacco mosaic virus:

A

Tobacco mosaic virus (TMV) is a widespread plant pathogen affecting many species of plants including tomatoes. It gives a distinctive ‘mosaic’ pattern of discolouration on the leaves which affects the growth of the plant due to lack of photosynthesis.

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6
Q

Explain the causes, effects and treatments of Salmonella:

A

Salmonella food poisoning is spread by bacteria ingested in food, or on food prepared in unhygienic conditions. In the UK, poultry are vaccinated against salmonella to control the spread. Fever, abdominal cramps, vomiting and diarrhoea are caused by the
bacteria and the toxins they secrete.

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7
Q

Explain the causes, effects and treatments of Gonorrhoea:

A

Gonorrhoea is a sexually transmitted disease (STD) with symptoms of a thick yellow or green discharge from the vagina or penis and pain on urinating. It is caused by a bacterium and was easily treated with the antibiotic penicillin until many resistant strains appeared. Gonorrhoea is spread by sexual contact. The spread can be controlled by treatment with antibiotics or the use of a barrier method of contraception such as a condom.

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8
Q

Explain the causes, effects and treatments of Rose black spots:

A

Rose black spot is a fungal disease where purple or black spots develop on leaves, which often turn yellow and drop early. It affects the growth of the plant as photosynthesis is reduced. It is spread in the environment by water or wind. Rose black spot can be treated by using fungicides and/or removing and destroying the affected leaves.

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9
Q

What type of disease is Malaria?

A

The pathogens that cause malaria are protists.
The malarial protist has a life cycle that includes the mosquito. Malaria causes recurrent episodes of fever and can be fatal. The spread of malaria is controlled by preventing the vectors, mosquitos, from breeding and by using mosquito nets to avoid being bitten

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10
Q

What is the first line of defence against pathogens?

A

These first lines are general defences, and are not specific to fight against certain types of pathogen. The skin covers almost all parts of your body to prevent infection from pathogens. If it is cut or grazed it immediately begins to heal itself, often by forming a scab, which prevents infection as the skin acts as a physical barrier. Parts of the body that do not have skin have developed other ways to prevent infection. For example, the eyes produce tears, which contain enzymes, and these are chemical barriers.

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11
Q

How does the Nose defend from pathogens?

A

The nose has internal hairs, which act as a physical barrier to infection. Cells in the nose produce mucus. This traps pathogens before they can enter the lungs. When the nose is blown, mucus is removed and any pathogens are trapped within it.

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12
Q

How does the trachea and bronchi defend from pathogens?

A

The trachea runs from the nose towards the lungs. The cells that line the trachea also have hairs called cilia, which are much smaller than those in the nose. These are called ciliated cells. The ciliated cells waft their hairs and move mucus and pathogens upwards towards the throat where it is swallowed into your stomach. Other cells called goblet cells create the mucus in order to trap pathogens. The production of mucus in your airways is a physical barrier.

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13
Q

How does the stomach defend from pathogens?

A

Stomach acid does not break down food. It is part of the body’s non-specific first line of defence. It is hydrochloric acid and while it does us no harm, it is strong enough to kill any pathogens that have been caught in mucus in the airways or consumed in food or water. Stomach acid is a chemical barrier against infection.

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14
Q

Explain how phagocytes defend the body from pathogens:

A

Phagocytes are white blood cells. They are attracted to pathogens. They surround them in the blood, bind to them and engulf them.

The phagocytes’ membrane surrounds the pathogen and the enzymes found inside the cell, then break down the pathogen in order to destroy it. As phagocytes do this to all pathogens that they encounter, we call them ‘non-specific’.

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15
Q

Explain how Lymphocytes defends the body from pathogens:

A

They recognise proteins on the surface of pathogens called antigens. Lymphocytes detect that both the proteins and pathogens are foreign, not naturally occurring within your body and produce antibodies. This can take a few days, during which time you may feel ill. The antibodies created by the lymphocytes cause pathogens to stick together, and make it easier for phagocytes to engulf them.

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16
Q

What are antibodies?

A

A protein produced by the immune system in humans that attack foreign antigens in the body

17
Q

What are antigens?

A

A protein on the top of a substance (often a pathogen) that triggers an immune response.

18
Q

What are memory cells?

A

a memory lymphocyte can ‘remember’ the antigens from an infection by a previous pathogen. A second exposure to it will result in a much faster immune response. Antibodies will be produced much faster, which often stops us becoming ill again. There are hundreds of common colds caused by different viruses. It is very unlikely you will become infected by the same virus because memory lymphocytes exist to fight the infection immediately. This response to a known antigen is called the secondary response and it is much quicker than the response to an antigen for the first time.

19
Q

Explain the cycle of antibodies production:

A

During the primary infection the antibodies slowly increase, peak at around ten days and then gradually decrease. A second exposure to the same pathogen causes the white blood cells to respond quickly in order to produce lots of the relevant antibodies, which prevents infection.

20
Q

Explain the cycle of antibodies production:

A

During the primary infection the antibodies slowly increase, peak at around ten days and then gradually decrease. A second exposure to the same pathogen causes the white blood cells to respond quickly in order to produce lots of the relevant antibodies, which prevents infection.

21
Q

How do vaccinations prevent illness?

A

Vaccination involves introducing small quantities of dead or inactive forms of a pathogen into the body to stimulate the white blood cells to produce antibodies. If the same pathogen re-enters the body the
white blood cells respond quickly to produce the correct antibodies, preventing infection.

22
Q

How do antibiotics treat illnesses?

A

Antibiotics, such as penicillin, are medicines that help to cure bacterial disease by killing infective bacteria inside the body. It is important that specific bacteria should be treated by specific
antibiotics.

23
Q

Explain the phases of drug testing?

A

New medical drugs have to be tested and trialled before being used
to check that they are safe and effective.
New drugs are extensively tested for toxicity, efficacy and dose.
Preclinical testing is done in a laboratory using cells, tissues and
live animals.
Clinical trials use healthy volunteers and patients.
* Very low doses of the drug are given at the start of the clinical
trial.
* If the drug is found to be safe, further clinical trials are carried
out to find the optimum dose for the drug.
* In double blind trials, some patients are given a placebo.