Infection Flashcards
Risk factors of infective endocarditis
Previous episode of infective endocarditis
rheumatic valve disease (30%)
prosthetic valves
congenital heart defects
intravenous drug users (IVDUs, e.g. typically causing tricuspid lesion)
Signs of infective endocarditis
splinter haemorrhages
new/worsening murmur (rare)
janeway lesions
Oslers nodes
Symptoms of infective endocarditis
fever/night sweats malaise anorexia weakness arthralgia headache SOB chest pain
Investigations in suspected infective endocarditis
FBC, CRP, U&Es Urinalysis ECG Echo Blood cultures: 3 separate at spike of fever prior to antibiotics therapy from different locations
What might you seen in urinalysis in infective endocarditis
RBC casts
WBC casts
proteinuria
pyuria
What may you see on ECG as infective endocarditis progresses
prolonged PR interval
non-specific ST/T wave abnormalities
AV block
What might you see on Echo in infective endocarditis
valvular mobile vegetations
What is the management of infective endocarditis
- supportive
- empirical antibiotic therapy
- surgery to debride infected tissue/valves
What are the complications of infective endocarditis
- congestive heart failure
- systemic emboli
- anterior mitral valve vegetation
- valvular rupture
What is Acute rheumatic fever
- Autoimmune disease that may occur following group A streptococcal throat infection
- Can affect joints, heart, brain, and skin.
What are the common features of Rheumatic fever
- Joint pains
- Sore throat/scarlet fever
- Malaise
- Fever
- Chest pain/murmur/palpitations
- SOB
- Pericardial rub
Risk factors for rheumatic fever
- poverty
- overcrowded living
- FH/genetic susceptibility
- HLA association
Investigations when considering Rheumatic fever
- FBC, CRP/ESR, U&Es
- Blood cultures
- ECG: prolonged PR
- Echo: valvular dysfunction (mitral or aortic)
- throat culture
What pathogen usually causes rheumatic fever
beta-haemolytic streptoccocal A
What is the treatment of rheumatic fever
- Antibiotics - benpen
- If arthritis NSAIDs
- secondary prophylaxis
- valvular surgery