Anti-coagulation and Bleeding risk Flashcards

1
Q

What is warfarin

A

Vitamin K antagonist

Increases prothrombin time

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2
Q

What is prothrombin time

A

the time in which it takes blood to clot

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3
Q

What is INR

A
  • Assesses how anti-coagulated a person is on warfarin by comparing their prothrombin time with that of a normal healthy adult
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4
Q

What is the INR aimed for in a patient with AF

A

2-3

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5
Q

Warfarin is affected by which enzyme system in the liver

A

cytochrome P450

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6
Q

What everyday things influence cyctochrome P450

A

leafy greens
cranberry juice
alcohol

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7
Q

How do you reverse warfarin

A

vitamin K

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8
Q

How do you reverse warfarin

A

vitamin K

warfrin has a half like of 1-3 days

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9
Q

What is the half life of a NOAC and can you reverse it

A

Can’t reverse a NOAC

half life 7-15 hour half life

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10
Q

Advantages of NOACS

A

No monitoring is required
No major interaction problems
Equal or slightly better than warfarin at preventing strokes in AF
Equal or slightly less risk of bleeding than warfarin

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11
Q

What is the CHA2DS2-VASc tool

A

This is a tool for assessing whether a patient with atrial fibrillation should be started on anticoagulation

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12
Q

What does CHA2DS2-VASc take into account

A
C – Congestive heart failure
H – Hypertension                                      
A2 – Age >75 (Scores 2)
D – Diabetes
S2 – Stroke or TIA previously (Scores 2)
V – Vascular disease                                 
A – Age 65-74
S – Sex (female)
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13
Q

What is the HAS-BLED tool

A

an assessment tool for establishing a patient’s risk of major bleeding whilst on anticoagulation. It can be used prior to initiating anticoagulation or as a monitoring tool in patients with a high risk of bleeding

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14
Q

What is the role of a pacemaker

A

deliver controlled electrical impulses to specific areas of the heart to restore the normal electrical activity and improve the heart function.

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15
Q

What are the indications of a Pacemaker

A

Symptomatic bradycardias
Mobitz Type 2 AV block
Third degree heart block
Severe heart failure (biventricular pacemakers)
Hypertrophic obstructive cardiomyopathy (ICDs)

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16
Q

How long do pacemakers last

A

5 years

17
Q

What are Implantable Cardioverter Defibrillators

A

Implantable Cardioverter Defibrillators continually monitor the heart and apply a defibrillator shock to cardiovert the patient back in to sinus rhythm if they identify a shockable arrhythmia.