INFEC Rx

Question 1

Hepatitis A

Answer 1

No specific Rx

Mx is supportive

Question 2

Hepatitis B

Answer 2

Antiviral therapy
- entecavir / tenofovir

Pegylated alpha-interferon

Liver transplantation

Question 3

Hepatitis C

Answer 3

Pegylated alpha-interferon
Ribavirin

Liver transplant

Question 4

Hepatitis D

Answer 4

Pegylated alpha-interferon

Liver transplant

Question 5

Hepatitis E

Answer 5

No licensed Rx
Acute HEV is usually self-limiting
Ribavirin monotherapy in immunocompromised

Question 6

Bacterial Meningitis

Answer 6

Abx - benzylpenicillin / ceftriaxone
Steroids - dexamethasone
Supportive therapy

Question 7

Gastro-enteritis

Answer 7

Rehydration w/ oral salt / glucose solution or IV saline
Fasting
Antimicrobials
Treatment of Cx

Question 8

HIV

Answer 8

Combo antiretroviral therapy (cART)

• nucleoside reverse transcriptase inhibitors
• non-nucleoside reverse transcriptase inhibitors
• protease inhibitors
• integrase inhibitors

Question 9

Sepsis

Answer 9

Oxygen
IV antibiotics
IV fluid challenge

Question 10

Influenza

Answer 10

Oseltamivir (Tamil)
Zanamivir (Relenza)
Peramivir
Favipiravir

Seasonal flu vaccine

Question 11

Uncomplicated Malaria

Answer 11

Malarone 3 days
or
Quinine 7 days + oral doxycycline / clindamycin

Question 12

Typhoid Fever

enteric fever

Answer 12

Oral azithromycin

IV ceftriaxone

Question 13

Dengue Fever

Answer 13

No specific Rx agents
Prevention
- Avoid bites (duh)
- New vaccine

Question 14

Schistosomiasis

Answer 14

Praziquantel

Prednisolone if severe

Question 15

Rickettsiosis

Answer 15

Tetracycline

Question 16

Zika Virus

Answer 16

No antiviral therapy
Mosquito control measures
Vaccine in development

Question 17

Impetigo

Answer 17

Topical Abx

Topical Rx + oral Abx - flucloxacillin

Question 18

Erysipelas

Answer 18

Anti-staphylococcal Abx
+ Anti-streptococcal Abx

If severe - admission for IV Abx + rest

Question 19

Cellulitis

Answer 19

Anti-staphylococcal Abx
+ Anti-streptococcal Abx

If severe - admission for IV Abx + rest

Question 20

Folliculitis

Answer 20

No Rx

Topical Abx

Question 21

Furunculosis

Answer 21

No Rx
Topical Abx
Oral Abx if no improvement

Question 22

Carbuncles

Answer 22

Hospital admission
Surgery
IV Abx

Question 23

Necrotising Fasciitis

Answer 23

Surgical review
Broad spectrum Abx 
- flucloxacillin
- gentamicin
- clindamycin

Question 24

Pyomyositis

Answer 24

Drainage w/ Abx cover

- depends on gram stain + culture results

Question 25

Septic Bursitis

Answer 25

Abx Steroids Surgical drainage

Question 26

Infectious Tenosynovitis

Answer 26

Empiric Abx | Hand surgeon review ASAP

Question 27

Staphylococcal Toxic Shock Syndrome

Answer 27

``` Remove offending agent eg tampon IV fluids Inotropes Abx IV immunoglobulins ```

Question 28

Streptococcal Toxic Shock Syndrome

Answer 28

Urgent surgical debridement of infected tissues - mortality rate 50% (much higher than staph TSS)

Question 29

Infectious Diarrhoea b/c protozoa parasite

Answer 29

Metronidazole ± luminal agent to clear colonisation

Question 30

Complicated Malaria

Answer 30

IV quinine + oral doxycycline / clindamycin when patient is stable and able to swallow switch to oral treatments

Question 31

Clostridium difficile infection

Answer 31

``` Stop precipitating Abx Oral metronidazole Oral vancomycin if 2+ severity markers Stool transplant Surgery ```

Question 32

E coli 0159

Answer 32

Rx supportive NOT Abx

Question 33

Rabies

Answer 33

Post-exposure prophylaxis immediately after bite - human rabies immunoglobulin (HRIG) - 4 doses of rabies vaccine over 14 days

Question 34

Brucellosis

Answer 34

Doxycycline Rifampicin IM gentamicin

Question 35

Leptospirosis

Answer 35

``` Abx in early phase Doxycycline in mild IV penicillin in severe Prompt dialysis Mechanical ventilation ```

Question 36

Lyme borrelios

Answer 36

Oral doxycycline / amoxicillin / IV ceftriaxone

Question 37

Staph aureus bacteraemia

Answer 37

Abx Mx - flucloxacillin - vancomycin - teicoplanin - linezolid - daptomycin