Inducers and Inhibitors of CYP450 Activity

Question 1

Cytochrome P450 1A2

Answer 1

Inducers:
Phenobarbital, Rifampin, Tobacco/ marijuana smoke

Inhibitors:
Cimetadine, Erythromycin, Clarithromycin

Question 2

Cytochrome P450 2C8

Answer 2

Inducers:
Phenobarbital

Inhibitors:
None from list we need to know.

Question 3

Cytochrome P450 3A4

Answer 3

Inducers:
Phenobarbital, Phenytoin, Cabamezapine, Rifampin, St. John’s Wort

Inhibitors:
Cimetadine, Erythromycin, Clarithromycin, Antifungal agents (Ketoconazole, Itraconazole), Grapefruit Juice, Fluoxetine (and Other SSRIs), HIV Protease Inhibitors

Question 4

Cytochrome P450 2C9

Answer 4

Inducers:
Phenytoin, Carbamezapine, Rifampin

Inhibitiors:
None from list we need to know

Question 5

Cytochrome P450 2C18

Answer 5

Inducers:
Rifampin

Inhibitors:
None from list we need to know

Question 6

Cytochrome P450 2E1

Answer 6

Inducers:
Ethanol

Inhibitors:
None from list we need to know

Question 7

Cytochrome P450 2D6

Answer 7

Inducers:
None from list we need to know

Inhibitors:
Cimetadine, Fluoxetine (and other SSRIs)

Question 8

Cytochrome P450 2C19

Answer 8

Inducers:
None from list we need to know

Inhibitors:
Omeprazole