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Pharmacology Drug Targets > Drug Overdoses and Antidotes > Flashcards

Drug Overdoses and Antidotes Flashcards

1
Q

Acetaminophen

A

N-acetylcysteine (replenishes glutathione)

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2
Q

AChE inhibitors, organophosphates

A

Atropine> pralidoxime

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3
Q

Amphetamines (basic)

A

Ammonium Chloride (acidify urine- ion trapping)

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4
Q

Antimuscarinic, anticholinergic agents

A

Physostigmine salicylate, control hyperthermia

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5
Q

Benzodiazepines

A

Flumazenil

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6
Q

Beta Blockers

A

Glucagon

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7
Q

Carbon Monoxide

A

100% O2, hyperbaric O2

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8
Q

Copper, arsenic, gold

A

Penicillamine

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9
Q

Cyanide

A

Nitrite + thiosulfate, hydroxocobalamin

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10
Q

Digitalis (digoxin)

A

Anti-dig Fab fragments

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11
Q

Heparin

A

Protamine sulfate

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12
Q

Iron

A

Deferoxamine, deferasirox

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13
Q

Lead

A

EDTA, dimercaprol, succimer, penicillamine

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14
Q

Mercury, arsenic, gold

A

Dimercaprol (BAL), succimer

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15
Q

Methanol, ethylene glycol (antifreeze)

A

Fomepizole> ethanol, dialysis

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16
Q

Methemoglobin

A

Methylene blue, vitamin C

17
Q

Opiods

A

Naloxone (Narcan), naltrexone

18
Q

Salicylates

A

Sodium Bicarbonate (alkalinize urine), dialysis

19
Q

TCAs

A

Sodium Bicarbonate (plasma alkalinization)

20
Q

tPA, streptokinase, urokinase

A

Aminocaproic acid

21
Q

Warfarin

A

Vitamin K (delayed effect), fresh frozen plasma (immediately)

Pharmacology Drug Targets (3 decks)

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