indole alkaloids Flashcards
source of strychnine , what is it a derivative of
found in the seeds of Strychnos nux-
vomica L. (family Loganiaceae).
tryptamine deriv
source of physositgamine , what is it a derivative of
found in calabar beans
used as a salicylates salt
derivivtive of tryptamine
what is physosigamine used for
myasthenia gravis but its replaced with neostigmine
source of vincrisitine and vinblastine
found in the herbs of Catharnuthus roseus of the family Apocynanaceae
dimeric alkaloid with indole/indoline system the only 2 out of the 80 used medicinally as anti cancer agents
what kind of salt used for vincrsine and vinblastine
sulfate salts
mention where you can find indole alkaloids that are of tryptamine derivites
neurotransmitter serotonin
hormone melatonin
in the seeds of Strynchos nuxvomica L. Logan’s case - strychnine
in calabar beans - physiostigmine
in catharunus roseaus. vincris and vinblast
pharm active psylobin , DMT and DET
SYNTHETIC tryptamine sumitrupan
occurs in various species of vines of convolvulaceae
Ergine aka LSA aka lysergamide
amide of D-lysergic acid (primary amide)
example of B-carboline derivatives and the source and what kind of alkaloids it contain
Rauwolfia alkaloids
they are found in the roots and rhizomes of Rauwolfia serpentina (family Apocynaceae)
diester alkaloids
names of Rauwolfia alkaloids
they are diester alkaloids
-Reserpine
-Recinnamine
-Deserpidine
what are rauwolfia alkaloids used for
hypotensives and tranquilizers
which alkaloid is used as a malate salt?
ergometrine (ergonovine) - it is water soluble freely
ergometrine
water soluble
potent oxytocin drug
used to prevent post partum hemorrage
ergotamine
water insoluble used as tartate salt
used to treat acute migraine attacks
slower onset of action and longer DOA than ergometrine
ergocryptine
used to produce bromocriptine via bromination
bromocriptine is a hormone suppresent used in endocrine disorders, used to suppress the production of growth hormone prolactin
parent compound of phenylalklyamines
phenylethylamine
it is not an alkaloid not found in plants / nature
how did we get phenylethylamine
it is biosynthezied from phenylalanine via enzymatic decarboxylation of phenylalanine
subclasses of phenylethylamines
simple derivatives - ephedrine, mescaline , cathine
complex derivatives- colchicine
