Indirect sympathomimetics

Question 1

Amphetamine

Answer 1

Indirect general agonist, reuptake inhibitor, also Narcolepsy, obesity, ADHD.
releases stored catecholamines.

Question 2

Cocaine

Answer 2

Indirect general agonist, reuptake inhibitor.
Causes vasoconstriction and local anesthesia.
Caution when giving B-blockers if cocaine
Causes mydriasis in eyes with intact sympathetic innervation - used to confirm Horner syndrome.
intoxication is suspected (unopposed o activation → 1 1 1 BP, coronary vasospasm).

Question 3

Ephedrine

Answer 3

Indirect general agonist, releases stored catecholamines.
Nasal decongestion (pseudoephedrine), urinary incontinence, hypotension.