Indiciations Flashcards
Biguanides (Metformin, Metformin ER)
First line for T2 DM
- Lowers A1C
- Decreases TGs and LDLs
- Increases HDLs
- Targets FBG
Sodium-Glucose Cotransporter 2 Inhibitor (Canagliflozin, Dapagliflozin, Empagliflozin, Ertugliflozin)
T2 DM
- lowers BG and A1C
- Can also decrease the risk of CV events / disease
GLP-1 Agonists (Exenatide, Albiglutide, Duaglutide, Lixisenatide, Semaglutide, Liraglutide)
Diabetes
- increases insulin sensitivity
- lowers glucose (lowers A1C)
- helps protect the heart
*Liraglutide is approved for weight loss
DPP-IV Inhibitors (sitagliptin, saxagliptin, linagliptin, alogliptin)
Diabetes
- lowers A1C
- targets ppFBG
- approved for monotherapy
- can be used in renal impairment
Sulfonylureas (1st Gen = Chlorpropamide; 2nd Gen = Glyburide, Micronized, Glipizide, Glimepiride)
Diabetes
- targets both FBG and ppBG
- lowers A1C
- Glipizide = 2nd safest drug in renal impairment
Thiazolidinediones (Pioglitazone, Rosiglitazone)
Diabetes
- NOT first line
- lowers A1C a little bit
- lowers ppBG or FBG
Alpha-Glucosidase Inhibitors (Acarbose, Miglitol)
Diabetes
- lowers A1C
- Targets ppBG
Amylin Analog
Diabetes (T1 or T2)
- weight loss
- reduces appetite / food intake
- use in uncontrolled pts using mealtime insulin
- can use with or without sulfonylurea and/or metformin
- lowers A1C
- targets ppBG
Insulins (General)
Required for T1 DM
Progressed T2 DM
Gestational DM
Long-Acting (Basal) Insulins (Glargine, Detemir)
T1 or T2 DM
Ultra Long-Acting Insulins (Degludec)
T1 or T2 DM
Rapid-Acting Insulins (Aspart, Lispro, Glulisine, Afrezza)
Targets ppBG (BG peaks 1-2 hours after a meal)
Short-Acting Insulins
Use this in pumps
Intermediate-Acting Insulins (Neutral Protamine Hagedorn, Humulin N, Novolin N)
??? ASK ABOUT THIS
Premixed Insulins (premixed intermediate actin-g insulins)
??? ASK ABOUT THIS
