Indications Flashcards

1
Q

What conditions indicate topical antibiotic meds?

A

superficial skin infections and ocular surface disease: bacterial conjunctivitis, bacterial keratitis, blepharitis, external hordeola

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2
Q

What conditions indicate prophylactic infection treatment with antibiotics?

A

pre-op and post-op, corneal abrasion, recurrent corneal erosion, conjunctival abrasion +FBS

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3
Q

What conditions indicate oral antibiotics?

A

skin and soft tissue infection: internal hordeola, pre-septal cellulitis, dacryoadenitis, dacryocystitis

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4
Q

What conditions indicate injectable antibiotics?

A

intraocular and intraorbital infections: endophthalmitis, orbital cellulitis

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5
Q

What medication is indicated if you need gram (+) coverage peptidoglycan cell wall inhibitor?

A

bacitracin (in ointment form only, because in solution, it is replaced by gramicidin)

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6
Q

What medication is indicated if you need gram (+) coverage and MRSA coverage peptidoglycan cell wall inhibitor?

A

vancomycin

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7
Q

When would a compounded ophthalmic vancomycin be indicated?

A

when other antibiotics are not effective, especially with corneal ulcer

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8
Q

T/F MRSA is resistant to all b-lactam antibiotics

A

true

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9
Q

What drug is indicated for gram (+) and some (-) in the penicillin group?

A

aminopenicillins: amoxicillin and augmentin

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10
Q

What coverage does augmentin have?

A

gram (+) limited (-) and Haemophilus

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11
Q

Which cephalosporins have the best gram (+) coverage with some (-)?

A

cefazolin and cephalexin (Keflex)

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12
Q

Which cephalosporins have improved gram (-) and decreased gram (+)?

A

cefaclor

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13
Q

Which cephalosporin is good for children?

A

cefaclor

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14
Q

Which cephalosporins have FURTHER improved gram (-) and decreased gram (+)?

A

cefdinir, ceftriaxone, ceftazidime

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15
Q

Which cephalosporin is indicated for gonorrhea?

A

ceftriaxone (IM)

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16
Q

Which cephalosporin is indicated for orbital cellulitis?

A

ceftriaxone (IV)

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17
Q

What coverage do aminoglycosides have?

A

gram (-) including pseudomonas; topicals have some gram (+)

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18
Q

What coverage does tobramycin have that the other aminoglycosides do not?

A

MRSA

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19
Q

Rank to aminoglycosides according to pseudomonas coverage

A

tobramycin>gentamicin>neomycin

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20
Q

Which aminoglycosides can be fortified for corneal ulcer?

A

gentamicin and tobramycin

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21
Q

Which aminoglycoside is broad spectrum but has holes against pseudomonas and streptococcus?

A

neomycin

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22
Q

What coverage do tetracyclines have?

A

gram (+) and (-) including MRSA

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23
Q

What drug is indicated for lyme disease?

A

tetracycline

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24
Q

What are the two DOC for inclusion conjunctivitis?

A

doxycycline AND azithromycin

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25
Q

What are the five drugs indicated for inclusion conjunctivitis?

A

doxycycline, erythromycin, azithromycin, ofloxacin, levofloxacin

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26
Q

Which drug is indicated for rosacea and blepharitis?

A

doxycycline

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27
Q

What are two off-label uses of doxycycline?

A

pterygium and RCE

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28
Q

Which macrolide is narrow spectrum?

A

erythromycin

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29
Q

What is erythromycin ointment used for?

A

ocular surface infection and prophylaxis of ophthalmic neonatorum

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30
Q

What coverage does azithromycin have?

A

gram (-), (+) and chlamydia

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31
Q

What is the ophthalmic solution of azithromycin indicated for?

A

gram (+) and haemophilus, bacterial conjunctivits

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32
Q

What is clindamycin coverage?

A

primarily gram (+) including MRSA and some gram (-)

33
Q

Which drug is usually reserved for serious infections in patients with PCN allergy?

A

clindamycin

34
Q

What is the linezolid coverage?

A

gram (+) including MRSA

35
Q

What are second gen FLQs (ciprofloxacin and ofloxacin) indicated for?

A

bacterial conjunctivitis and bacterial corneal ulcers

36
Q

What is levofloxacin indicated for?

A

bacterial conjunctivitis (inclusion conjunctivitis)

37
Q

What is levofloxacin off label for?

A

corneal ulcer

38
Q

What coverage does 4th gen FLQs have?

A

gram (+) and some (-)

39
Q

What coverage does 2nd gen FLQs have?

A

gram (-) and some (+)

40
Q

What coverage does 3rd gen FLQs have?

A

gram (+) and some (-)

41
Q

What coverage does besivance (besifloxacin) have?

A

gram (+), a little (-), MRSA

42
Q

What are fourth gen FLQs indicated for?

A

bacterial conjunctivitis

43
Q

Which FLQ has very little resistance?

A

besifloxacin (Besivance)

44
Q

What coverage does Bactrim/Septra (sulfamethoxazole) have?

A

gram (+), (-), MRSA

45
Q

Which folic acid DNA synthesis inhibitor is good for pt with PCN allergy?

A

trimethoprim aka Bactrim/Septra

46
Q

What coverage does Polytrim (polymyxin B + trimethoprim) have?

A

gram (-), pseudoman, gram (+), MRSA

47
Q

What is Polytrim indicated for?

A

ocular surface bacterial infections

48
Q

What coverage dose Polumyxin B have?

A

gram (-) especially pseudomonas

49
Q

What is trifluridine (Viroptic) indicated for?

A

epithelial or stromal HSV

50
Q

When is FreshKote indicated?

A

Fuch’s dystrophy, RCE, EBMD

51
Q

When is Restasis indicated?

A

inflammatory DES, Sjogrens, SLE, refractive surgery, aqueous deficient dry eye

52
Q

What is loteprednol 0.25%/Eysuvis indicated for?

A

short term relief of dry eye signs and symptoms

53
Q

What treatment is indicated for blepharitis in general?

A

lid hygiene, antibiotic/corticosteroid

54
Q

What treatment is indicated for demodex?

A

tea tree oil

55
Q

What antibiotics are indicated for blepharitis/MGD?

A

doxycycline or minocycline (good for rosacea, MGD, RCE, and reducing K scarring)

56
Q

What are indications for amniotic membranes?

A

RCE, severe dry eye, neurotrophic K, persistent epithelial defects, chemical burns, SJS, microbial ulcers, HSV, VZV

57
Q

What is indicated to rapidly reduce IOP in an emergency (acute angle closure)?

A

systemic hyperosmotics (glycerin or mannitol)

58
Q

What is the indication for topical hyperosmotic?

A

corneal edema, RCE, Fuchs, EBMD

59
Q

What are management options for ocular allergies in general?

A

mast cell + antihistamine combo, corticosteroid, NSAID, mast cell stabilizer, decongestant, decongestant + antihistamine combo, antihistamine

60
Q

Which corticosteroid is approved for treatment of allergic conjunctivitis?

A

alrex (loteprednol)

61
Q

Which corticosteroids are off label for allergic conjunctivitis?

A

lotemax (loteprednol), Pred Forte, FML, Flarex

62
Q

Which NSAID is indicated for ocular itching due to SAC?

A

acular (ketorolac)

63
Q

What drops are indicated for the relief of eye redness?

A

phenylephrine, naphazoline, tetrahydrozoline, oxymetazoline

64
Q

What are the decongestant + antihistamine combos indicated for?

A

allergic conjunctivitis

65
Q

Which topical antihistamine is indicated for allergic conjunctivitis?

A

emadine (emedastine)

66
Q

Which mast cell stabilizer is indicated for allergic conjunctivitis?

A

alocril (nedocromil)

67
Q

Which mast cell stabilizer is indicated for VKC?

A

alomide (lodoxamide) and crolom (cromolyn sodium)

68
Q

What are topical acute HSV treatment options?

A

trifluridine (viroptic) or ganciclovir (zirgan)

69
Q

What are the oral HSV treatment options?

A

famciclovir, acyclovir, valacyclovir

70
Q

Which antiviral is indicated for long-term prophylactic treatment of HSV epithelial keratitis?

A

acyclovir

71
Q

T/F there are no topical treatment options for VZV/HZO?

A

true, only oral

72
Q

What are the oral treatment options for VZV/HZO?

A

famciclovir, acyclovir, valacyclovir

73
Q

What antiviral treatment is approved for adenovirus infections?

A

none

74
Q

What is the indication of betadine 5%?

A

off label use in EKC

75
Q

What are treatment options for adenovirus infection?

A

palliative (artificial tears, cool compress), topical corticosteroid (infectious interval is prolonged but patient comfort improves), zirgan, betadine

76
Q

What is the only approved topical anti-fungal?

A

natamycin

77
Q

What does natamycin cover?

A

candida, aspergillus, cephalosporium, fusarium, penicillium

78
Q

What is amphotericin B indicated for?

A

non-filamentous and yeast

79
Q

What treatment is indicated for acanthamoeba keratitis?

A

polyhexamethyl biguanide 0.02% (PHMB, Baquacil) and likely oral NSAID or narcotic analgesic (Ultram, Lortab, ibuprofen)