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Pharm II Exam 2 > Indications > Flashcards

Indications Flashcards

1
Q

L-triiodothyronine (T3)

Liothyronine Sodium

A

Not used much

Shorter HL because T3 so must be given multiple times a day

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2
Q

L-thyroxin (T4)

Levothyroid Sodium

A

Drug of choice for hypothyroidism

1x daily

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3
Q

Liotrix

T4:T3 at 4:1

A

Not usually necessary because body converts T4 to T3 (may be good if polymorphism in deiodinase enzyme)

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4
Q

Thioamides - PTU and MMI

A

Mild -Moderate hyperthyroidism

Tx for preop thyroidectomy for ~6 wk until euthyroid

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5
Q

Propylthiouracil

PTU

A

Thyroid storm

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6
Q

Anion Inhibitors- (ClO4-) and (TeO4-)

A

Block thyroidal uptake of iodide in patients with iodide induced hyperthyroidism
(such as amiodarone induced hyperthyroidism)

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7
Q

Iodide

A

Hyperthyroidism rarely used (thioamides are better)

Can use in combo with PTU and B-blocker in thyroid storm (acute thyroid crisis)

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8
Q

Radioactive Iodine

I131

A

Thyrotoxicosis

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9
Q

First line tx for DM2

A

exercise & weight control

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10
Q

Metformin

A

First line med for type 2 diabetes

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11
Q

Glipizide

A

DM2

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12
Q

Repaglinide

A

DM2

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13
Q

Pioglitazone

A

DM2

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14
Q

Exenatide

A

DM2

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15
Q

Sitagliptin

A

DM2

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16
Q

Acarbose

A

DM2

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17
Q

Canagliflozin

A

DM2

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18
Q

What are agonist uses of Estrogens and Progestins?

A

Menopausal hormone therapy

Contraception

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19
Q

What are antagonist uses of Estrogens and Progestins?

A

Hormone-responsive breast cancer therapy

Emergency contraception, medical abortion

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20
Q

Estrogens

A

Contraceptive (not used as single agent)

Estrogen deficiency

Hirsuitism, amenorrhea, dysfunctional uterine bleeding, dysmenorrhea

21
Q

Progestins

A

Contraception

22
Q

Levonorgest

A

Emergency Contraceptive within first 120 hrs post-unprotected sex

23
Q

Norethindrone

A

contraception

24
Q

Progesterone

A

contraception

25
Q

Progestin only pill

A

contraception

26
Q

Estrogen/Progestin Combo Pill

A

Contraception

27
Q

Ulipristal

A

Emergency Contraceptive within first 120 hrs post-unprotected sex

Uterine fibroids

28
Q

Mifepristone

RU486

A

Termination of early pregnancies along with PGE1(misoprostal)

Emergency contraception (not drug of choice)

29
Q

Tamoxifen

A

Treat early stage or metastatic ER+ breast cancer in pre- or post- menopausal patients

↓ risk of cancer
development

Note that ER+/PR+/HER2- pts respond best to SERMs

30
Q

Toremifene

A

Treat metastatic ER+ breast cancer in post- menopausal patients

31
Q

Leuprolide

A

Treat metastatic or early stage ER+ breast cancer in pre- menopausal patients

May be combined with SERMs

Note: ASCO does not consider this to be best treatment option for early stage breast cancer → consider tamoxifen

32
Q

Aromatase Inhibitors

A

Treat early stage or metastatic ER+ breast cancer in post- menopausal patients

More effective than tamoxifen (greater survival) in post- menopausal patients

33
Q

Trastuzumab

A

Metastatic HER2+ breast cancer resistant to trastuzumab and/or taxanes

34
Q

Pertuzumab

A

Metastatic HER2+ breast cancer; used in conjunction with trastuzumab and docetaxel

35
Q

Cyclophosphamide

A

Lymphomas

Leukemias

MM

Breast and ovarian ca

Small cell lung cancer

Some autoimmune conditions

36
Q

Cisplatin

A

Testicular/Ovarian ca

Bladder ca

Small and non-small cell lung ca

Colon ca

37
Q

Carmustine (bi-fn)

Lomustine and Semustine (mono-fn)

A

Brain tumors

38
Q

Streptozocin

A

Insulin-secreting islets carcinoma cells

39
Q

Methotrexate

A

Breast ca

Head & Neck ca

Bladder ca

Lung
carcinomas

Lymphomas

ALL

40
Q

5-Fluorouracil

A

Colon ca

Breast ca

Gastroesophageal ca

Hepatocellular ca

Pancreatic
carcinomas

41
Q

6-Mercaptopurine

A

ALL and AML

Crohn’s

42
Q

Vinblastine

A

Breast
cancer

Hodgkin’s and
non-Hodgkin’s lymphoma

43
Q

Vincristine

A

Childhood

leukemias and cancers

44
Q

Paclitaxel

A

Ovarian, breast, bladder,ca

Non-small cell lung
cancers

45
Q

Etoposide

A

Testicular ca

Non-small
cell and small cell
lung ca

AML and ALL

Hodgkin’s and non-Hodgkin’s
lymphoma

46
Q

Irinotecan

A

Metastatic

colon cancer

47
Q

Doxorubicin

A

Hodgkin’s
and non-Hodgkin’s

Breast, ovarian and
bladder ca

ALL

NOT good for solid tumors

48
Q

Bleomycin

A

Testicular carcinoma

SCC

Hodgkin’s and non-Hodgkin’s
lymphomas

49
Q

What drug can you use to prevent hyperuricemia during 6-MP tx of leukemias?

A

Allopurinol

Pharm II Exam 2 (7 decks)

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