Contraindications

Question 1

L-triiodothyronine (T3)

Liothyronine Sodium

Answer 1

Heart dz pts

Question 2

Iodide

Answer 2

Pregnancy→can cause fetal goiter

Question 3

Radioactive Iodine

I131

Answer 3

Children and pregnancy

Question 4

Metformin

Answer 4

Renal dysfn or severe liver dz

Lactic acidosis under conditions of Renal impairment (interferes with lactate metabolism)

Question 5

Sulfonylureas

Answer 5

Hepatic dz/ Renal dz

Caution in elderly/cardio pts

Question 6

GLP-1 Receptor Agonists

Answer 6

Gastroparesis

Question 7

α-Glucosidase Inhibitors

Answer 7

Chronic intestinal diabetes

Question 8

Estrogens

Answer 8

Pregnancy (risk of genital ca/growths)

Question 9

Progestins

Answer 9

Pregnancy

Personal hx breast ca

Undiagnosed vaginal bleeding

Active thromboembolic dz within last 6 mo (but ok in women with hx of thromboembolic dz)

Abnormal liver fn

Question 10

Estrogen/Progestin Combo Pill

Answer 10

CV dz, stropke, HTN (>160/90), thromboembolic dz or hypercoaguability, abnrml liver fn, hx breast ca, smokre >35 yo, migraine w/ neuro aura, vaginal bleeding of unk cause, pregnancy or breast feeding

Caution in pts w/ fibroids, diabetes, severe HA

Question 11

Ulipristal

Answer 11

Must r/o pregnancy first bc embryotoxic

Question 12

Mifepristone

RU486

Answer 12

Do not use if taking glucocorticoids

CYP3A4 drug interactions

Question 13

IUDs

Answer 13

Current STI (gonorrhea or chlamydia)

Unexplained uterine bleeding

Large deforming fibroids

Wilson’s disease or Copper allergy (copper only)

Question 14

Tamoxifen

Answer 14

Hx DVT or PE (however, for invasive breast cancer – benefits of tamoxifen outweigh risks)

Pregnancy

Question 15

Toremifene

Answer 15

Hx DVT

Pregnancy

Question 16

Leuprolide

Answer 16

Pregnancy

Question 17

Cyclophosphamide

Answer 17

CYP450 drug interactions (can cause liver tox)

Question 18

Methotrexate

Answer 18

Penicillin, cephalosporins and NSAIDs inhibit renal excretion of MTX* monitor closely