indication & moa Flashcards
general opioids: moa
agonist: μ κ δ - cns receptors
analgesic + some sedation
opioid reversal agent moa
stronger affinity to opioid receptors; knocks opioids off for a short time.
general: benzodiazepines - moa & indication
occupies GABA receptors, allowing build up of GABA
sedation, amnesia, anxiolysis, anticonvulsant
norepinephrine (Levophed) class/moa & indication
vasocontriction: alpha, beta-1 agonist only - no anti-histamine effect (not for anaphylaxis)
first line drug for septic shock
epinephrine (adrenaline) class/moa & indication
vasoconstriction: alpha, beta1, beta2 agonist
first line drug for cardiac arrest (ACLS)
cardiovascular collapse
anaphylaxis
first line drug for septic shock
norepinephrine (Levophed)
first line drug for cardiac arrest (ACLS)
epinephrine (adrenaline)
phenylephrine (NeoSynephrine, Afrin) class/moa & indication
vasoconstrictor (direct acting alpha agonist)
hypotension, shock
nasal congestion
vasopressin (Pitressin): class/moa & indication
direct vasoconstrictor - it’s ADH/DDAVP
hypotension, sepsis (endogenous vasopressin deficiency), cardiovascular collapse), diabetes insipidus
dopamine: vasoactive class/moa & indication
vasoconstrictor: alpha, beta1 agonist dopaminergic agonist (kidneys, mesentery)
DOSE DEPENDENT
low: dopaminergic
intermediate: dopaminergic, b1
high: alpha
hypotension, shock, impaired renal perfusion
neostigmine (Prostigmin): moa
reversible cholinesterase inhibitor
donepezil (Aricept): class/moa & indication
cholinesterase inhibitor
Alzheimer’s
rivastigmine (Exelon): class/moa & indication
cholinesterase inhibitor
Alzheimer’s
-curium and -ronium: class/moa
nicotinic cholinergic blocker - non-depolarizing neuromuscular blocker
succinylcholine (Anectine): class/moa
nicotinic cholinergic blocker - depolarizing neuromuscular blocker
