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Red Blood Cell And Bleeding Disorders > Increased Red Cell Destruction Determine Mechanism > Flashcards

Increased Red Cell Destruction Determine Mechanism Flashcards

1
Q

HS

A

Rec cell membrane disorder

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2
Q

Hereditary Elliptocytosis

A

Red cell membrane disorders

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3
Q

2 enzyme deficiencies in in inherited genetic disorders

A

Hexose monophosphatr shunt enzyme deficiencies

Glycolytic enzyme deficiencies

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4
Q

G6PD

A

Hexose monophosphatr shunt enzyme deficiencies

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5
Q

Glutathione synthetase deficiency

A

Hexose monophosphatr shunt enzyme deficiencies

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6
Q

Pyruvate kinase deficiency

A

Glycolytic enzyme deficiency

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7
Q

Hexokinase deficiency

A

Glycolytic enzyme deficiency

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8
Q

Hemoglobin abnormalities mechanisms

A

Deficient globin synthesis

Structurally abnormal globins

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9
Q

Thalassemia

A

Deficient globin synthesis

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10
Q

Sickle cell disease

A

Structurally abnormal globins

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11
Q

Unstable hemoglobins

A

Structurally abnormal globins

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12
Q

Acquired genetic defects mechanisms

A

Deficiency of phophatidylinositol-linked glycoproteins

Antibidy-mediated destruction

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13
Q

PNH

A

Deficiency of phsphatidylinositol-linked glycoproteins

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14
Q

Hemolytic disease of the new born (Rh disease)

A

Antibody-mediated destruction

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15
Q

Transfusion reactions

A

Antibody-mediated destruction

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16
Q

Drug induced

A

Antibody-mediated destruction

17
Q

Autoimmune disorders

A

Antibody-mediated destruction

18
Q

Mechanical trauma mechanisms in hemolysis

A 
Mucroangiopathi. Hemolytic anemias
Cardiac traumatic hemolysis
Repetitive physical trauma
Infections of red cells
Toxic or chemical injury
Membrane lipid abnormalities
Sequestration
19
Q

Hemolytic uremic syndrome

A

Microangiopathic hemolytic anemias

20
Q

DIC

A

Microangiopathic hemolytic anemias

21
Q

Thrombotic thrombocytopenia purpura

A

Microangiopathic hemolytic anemias

22
Q

Defective cardiac valves

A

Cardiac traumatic hemolysis

23
Q

Bongo drumming

A

Repititive physical trauma

24
Q

Marathon running

A

Repititive physical trauma

25
Q

Karate chopping

A

Repititive physical trauma

26
Q

Malaria

A

Infections of red cells

27
Q

Babesiosid

A

Infections of red cells

28
Q

Clostridial sepsis

A

Toxic or chemical injury

29
Q

Snake venom

A

Toxic or chemical injury

30
Q

Lead poisoning

A

Toxic or chemical injury

31
Q

Abetalipoproteinemia

A

Membrane abnormalities

32
Q

Severe hepatocellular liver disease

A

Membrane abnormalities

33
Q

Hypersplenism

A

Sequestration

Red Blood Cell And Bleeding Disorders (3 decks)

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