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Red Blood Cell And Bleeding Disorders > Decreased Cell Production > Flashcards

Decreased Cell Production Flashcards

1
Q

2 main mechanisms in decreased red cell production

A

Inherited genetic defects

Nutritional deficiencies

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2
Q

Inherited genetic defects mechanisms

A

Defects leading to stem cell depletion

Defects affecting erythroblast maturation

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3
Q

Fanconi anemia

A

Defects leading yo stem cell depletions

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4
Q

Telomerase defects

A

Defects leading yo stem cell depletions

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5
Q

Thalassemia syndromes

A

Defects affecting erythroblast maturation

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6
Q

Nutritional deficiency mechanisms

A 
Deficiencies affecting DNA synthesis
Deficiencies affecting hemoglobin synthesis
Erythropoietin deficiency
Immune-mediated injury of progenitors
Inflammation-mediated iron sequestration
Primary hematopoietic neoplasma
Space occupying marrow lesions
Infections of red cell progenitors
Unknown mechanisms
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7
Q

Vit b12 deficiency

A

Deficiency affecting DNA synthesis

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8
Q

Folate deficiency

A

Deficiency affecting DNA synthesis

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9
Q

Iron deficiency anemia

A

Deficiency affecting hemoglobin synthesis

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10
Q

Renal failure

A

Erythropoietin deficiency

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11
Q

Anemia of chronic disease

A

Erythropoietin deficiency

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12
Q

Aplastic anemia

A

Immune-mediated injury of progenitors

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13
Q

Pure red cell aplasia

A

Immune-mediated injury of progenitors

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14
Q

Anemia of chronic disease

A

Inflammation-mediated iron sequestration

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15
Q

Acute leukemia

A

Primary hematopoietic neoplasms

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16
Q

Myelodysplasia

A

Primary hematopoietic neoplasms

17
Q

Myeloproliferative disorders

A

Primary hematopoietic neoplasms

18
Q

Metastatic neoplasms

A

Space occupying marrow lesions

19
Q

Granulomatous disease

A

Space occupying marrow lesions

20
Q

Parvovirus b19 infectiin

A

Infections of red cell progenitors

21
Q

Endocrine disorders

A

Unknown mechanisms

22
Q

Hepatocellular liver disease

A

Unknown mechanisms

Red Blood Cell And Bleeding Disorders (3 decks)

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