Incontinence in small animals Flashcards

1
Q

Categories - urinary incontinence

A
  • neurogenic/ non-neurogenic
  • by presenting sign: congenital, overflow, stress, urge, paradoxical, by response to tx, hormonal
  • useful aid to problem solving but not dx
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2
Q

Causes of juvenile canine incontinence

A
  • ureteral ectopia
  • congenital USMI
  • genitourinary dysplasia
  • bladder hypoplasia
  • intersexuality
  • pervious urachus
  • neurological dz
  • combinations of above.
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3
Q

Causes of adult canine incontinence

A
  • USMI
  • prostatic dz
  • neurological dz
  • urogenital neoplasia
  • fistulae
  • bladder atony
  • cystitis
  • detrusor instability
  • pelvic masses
  • combinations/ others
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4
Q

Define and decribe USMI

A

= Urethral sphincter mechanism incompetence

  • common cause of incontinence in dogs, esp neutered bitches, although castated male dogs and entire bitches can bee affected
  • usually acquired but may be congenital and may occur with anatomical defects (ureteral ectopia, intersexuality)
  • usual sign is urine leakage during recumbency
  • severity of leakage variable
  • often follows neutering
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5
Q

Pathophysiology - USMI

A
  • mutlfactorial aetiology
  • medium-large breeds most commonly
  • factors: anatomical, hormonal, environmental, unknown
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6
Q

USMI - risk factors

A
  • prevalence 3-12% post-neutering
  • 75% cases develop within 3 years of neutering
  • certain breeds (irish setter, rottweiler, OESD, doberman)
  • docked dogs and dogs >20kg significantly more at risk
  • effect of prepubertal neutering unclear
  • causal effect on neutering unclear (not d/t adhesions, possibly oestrogen and protegesterone levels and gonadotrophin effects)
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7
Q

Dx - USMIA

A
  • PE unremarkable
  • Dx based on hx, CS, investigation, response to trial tx, r/o other causes
  • caudally positioned bladder neck is supportive but not diagnostic
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8
Q

USMI in mae dogs

A
  • uncommon
  • congenital/acquired
  • acquire more likely in castrated larger breeds
  • leak predominantly when recumbent (suggests similar mechanism of inreased abdominal pressure –> resting urethral resistane)
  • intrapelvic bladder neck adn castrration statistically signficant factors
  • responds to medical tx less well than bithc
  • sx described
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9
Q

What is ureteral ectopia?

A

= ureters pass bladder and open into urethra or occasionally into vagina

  • congenital > acquired
  • inherited/ familial in some breeds (golden retriever)
  • females> males
  • dogs > cats
  • bilateral/unilateral
  • openings may be single/ double/ elongated (troughs)
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10
Q

Describe differences between dog/cat ureteral ectopia

A
  • dogs most likely to have an intramural ectopic ureter

- cats usually have extramural ectopic ureter

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11
Q

CS - ureteral ectopia

A
  • continued dribbling urinary incontinence
  • may have severe scalding
  • frequently associated with UTIs
  • may have concomitant SMI
  • may have other abnormalities (hydronephrosis, hydroureter, rarely ureterocoeles)
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12
Q

Describe genitourinarydysplasia

A
  • rare cause of urinary incontinence in cats and v occasionally dogs
  • more common than ectopic ureters in cats
    = congenital developmental abnormality affecting vagina and urethra
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13
Q

Other causes - urinary incontinence - 4

A
  • INTERSEXUALITY: rare cause of juvenile incontinence, incontinence most frequently d/t urine refluxing into another structure, may also get concomitant SMI. Tx depends on underlying defect, frequently sx.
  • BLADDER HYPERPLASIA: rare, usually associated with other congenital defects e.g. bilateral ectopic ureters, diagnosed radiographically, signs d/t low volume, poorly compliant bladder –> overflow, guarded px
  • BLADDER ATONY: usually secondary to bladder distension, tight junctions in bladder wall disrupted –> atonic bladder and urinary retention with overflow, px guarded, tx requires indwelling catheter.
  • PERVIOUS URACHUS: v rare in cats/dogs, more likely in farm spp.
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14
Q

Approach - urinary incontinence

A

Hx –> PE –> clincail pathology (urine, investigate PUPD if present) –>trial tx if suspect USMI –> diagnostic imaging/ endoscopy

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15
Q

Role of diagnostic imaging in urinary incontinence

A
  • cause urinary incontinence

- result from incontinence

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16
Q

What diagnostic imaging should be used?

A
  • Plain films (RLR, VD)
  • IVU (IV urography)
  • Retrograde study: most useful as provides most information on intra-pelvic anatomy
  • ultrasound: confirm normal ureteral emptying into bladder, additional info on kidneys, bladder, prostate
  • others
17
Q

Outline endoscopy in urinary incontinence diagnosis

A
  • excellent visualisation: ectopic ureters, other lesions of urethra –> bladder neck which may –> incontience. Subjective indication of urethral tone
  • can facilitate biopsy
  • recently used to tx intramural ectopic ureters using a laser
  • no information of urethro-pelvic relationships
  • not widely available in UK
18
Q

Tx - urinary incontinence

A
  • ideally based on definitive diagnosis
  • without this tx is TRIAL and SYMPTOMATIC
  • not necessarily undesirable provided owners understand this is the case
19
Q

Medical tx - urinary incontinence

A
  • Tx UTI (base on C+S, confirm eradication)
  • Tx underlying systemic dz (PUPD may exacerbate or precipitate condition)
  • Diet if obese
  • specific medication depends on dx
20
Q

Medical tx - SMI in dogs

A
  • Phenlypropanolamine = PPA (most effective)
  • Ephedrine hydrochloride (cheaper)
    »> both of above are alpha-adrenergic agonists
21
Q

Which disorders have sx options?

A
  • only with definitive diagnosis
  • ureteral ectopia
  • USMI in dogs (female and male)
  • genuto-urinary dysplasia
  • congenital genito-urinary malformations
  • bladder, urethral or vaginal masses
  • prostatic dz
22
Q

Management pre-sx

A
  • UTI and obesity to be managed 1st

- owners should be given realistic expectations as success not guaranteed

23
Q

Sx tx options for SMI

A
  • MOST SUPPORT: colposuspension, urethropexy, prosthetic sphincter, endoscopic injection of collagen
  • OCCASIONAL REPORTS: vas deferens pexy, urethrocystoplasty (cats), sling urethroplasty, cysto-urethropexy, other transpelvic slings, other variations/ combinations
24
Q

Principles - sx for USMI

A
  • improve pressure transmission to bladder neck
  • increase urethral resistance
  • or both
25
Q

What is colposuspension?

A
  • oldest described method
  • aims to move and retian bladder neck into intra-abdominal position to allow equal pressure transmission to bladder and proximal urethra
  • also probably increases urethral resistance
  • bladder neck repositoned to an intra-abdominal position and fixed with non-absorbable sutures from prepubic tendon to vagina
26
Q

Describe urethropexy

A
  • similar to colposuspension but sutures placed from urethra to prepubic tissues
  • bladder neck relocated and fixed cranially
27
Q

What are prostehtic sphincters?

A
  • currently popular
  • increase urethral resistance
  • inflatable band placed around bladder neck
  • filled with saline via SC port to acheive right amount of resistance
  • allows post-op tweaks to achieve continence
28
Q

How is collagen (or synthetic alternatives) used?

A
  • injected into periurethral tissues to increase urethral resistance
  • may be done at open surgery or via an endoscopic injector
  • degraded over time
29
Q

Name 2 sx tx options of SMI in male dogs

A
  • Vas deference pexy

- prostatopexy

30
Q

Describe vas deferens pexy

A
  • sx to tx SMI in incontinent male dogs
  • essentially a male ‘colposuspension’ using deferent ducts
  • results obtained in UK not so good
31
Q

Desvribe prostatopexy

A
  • another essentially a male ‘colposuspension’ using prostate to pull bladder forward into abdominal cavity
  • no complications reported
32
Q

Sx options for ureteral ectopia

A
  • re-inplantation of ureter: creation of neo-ureterocystostomy for intra-mural ureters (sx, laser ablation). Ureteral transection and re-implantation for extra-mural ureters
  • ureteronephrectomy
33
Q

2 techniques for neo-ureterocystotomy

A

intramural vs extramural (tunneling) technique

34
Q

Complications - ectopic ureter re-implantation

A
  • continued incontinence
  • ascending infection and pyelonephritis
  • bladder oedema and dysuriaa
  • stenosis of new stoma
  • recanalisaiton of ligated distal ureter
  • wound breakdown
35
Q

Other sx tx for urinary incontinence

A
  • correction of congenital genito-urinary malformations
  • tx of prostatic dz (omentalisation, others)
  • excision of bladder, urethral and vaginal masses
  • permanent cystostomy (palliative, choose owner/ patient carefully)
36
Q

Define urinary incontinence

A

involuntary passage of urine

37
Q

How might you adjust medications for refractory cases of SMI? (REFERENCE ONLY)

A
  • increase dose of PPA (off license): TID dosing, watch for hypertension, irritability, anorexia, combine PA with estriol therapy
  • IMIPRAMINE: improves bladder storage function, apha adrenergic effects, anecdotally helps in some dogs
  • GnRH ANALOGUES: causes FSH and LH to fall, have been used successfully for management of refractory incontinence
38
Q

Medical options - neurogenic/atonic bladder

A
  • DRUGS TO REDUCE URETHRAL TONE: phenoxybenzamine, diazepam
  • DRUGS TO IMPROVE BLADDER TONE/CONTRACTILITY: bethanecol (only once bladder easily expressed)
  • PHYSICAL BLADDER EMPTYING: abdominal pressure, intermittent/ indwelling catheterisation, permanent cystostomy tube.