In-111 pentetriotide Flashcards
what is In-111 penetriotide
DTPA conjugate of octeotride
properties of IN-111 penetriotide
long acting synthetic analpog of hormone somatostatin
what does somatostain do
prevents release of growth hormone from pituitary gland and other hormones from GI system
certain tumors secrete these other hormones thus
they have great number of somatostatin receptos and can be visulaized by bind radioacive labaled octreotide receptors
octreotide used for
treating sumportoms when tumors oversecrete hormones
somatostatin=
growth hormone release inhibiting factor
bio T1/2
6 hours
how does it leave system
rapudly leaves blood after injection exclusively by kidneys
-at six hours 50% excreted via urine
-at 24 hours 85% excreted by urine
how much of bio T1/2 is in111 of non dtpa octreotide
1/10th
kit comes with
vial of freeze dried penetriotide which you mix gently with In111Cl3 at room temp for 30 min
what is dtpa attached to to provide binding site for indium
peptide
unlabeled penetritide kept at 2-8 degrees C
