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Pharm Formulas > Imunosuppresants > Flashcards

Imunosuppresants Flashcards

1
Q

Alemtuzumab target use and notes

A

CD52

CLL, MS

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2
Q

Bevacizumab

A

Target: VEGF

Use: Colorectal cancer, renal cell carcinoma, non-small cell lung cancer

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3
Q

Cetuximab

A

EGFR

Stage IV colorectal cancer, head and neck

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4
Q

Rituximab

A

CD20

B cell non-Hodgkin lymphoma, CLL, rheumatoid arthritis, ITP

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5
Q

Tastuzumab

A

HER2/Neu

Breast cancer, gastric cancer

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6
Q

Adalimumab, certolizumab, golimumab

A

Soluble TNF-alpha

IBD, rheumatoid arthritis, ankylosis spondylitis, psoriasis

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7
Q

Daclizumab

A

CD25

Relapsing MS

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8
Q

Eculizumab

A

Complement protein C5

Paroxysmal nocturnal hemoglobinuria

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9
Q

Natalizumab

A

Alpha4 interin

MS, crohn disease

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10
Q

Ustekinumab

A

IL12/IL23

Psoriasis, psoriatic arthritis

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11
Q

Bevacizumab

A

Antibody against VEGF

Used for solid tumors (colorectal cancer, RCC)

AE: Hemorrhage, blood clots, impaired wound healing

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12
Q

Erlotinib

A

Mech: EGFR tyrosine kinase inhibitor

Use: Non small cell lung carcinoma

AE: rash

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13
Q

Cetuximab

A

Use: Anti EGFR

Use: IV colorectal cancer, head and neck

AE: Rash, LFTs, diarrhea

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14
Q

Imatinib

A

Mech: Tyrosine kinase inhibitor of BCL-ABL and cKIT

Use: CML, GI Stromal tumors

AE: Fluid retention

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15
Q

Rituximab

A

Monoclonal antibody against CD20

Nonhodgkin lymphoma, CLL, ITP, rheumatoid arthritis

AE: Increased risk of progressive multi focal leukoencephalopathy

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16
Q

Bortezomib, carfilzomib

A

Mech: Proteasome inhibitors, arrest at G2-M phase

Use: Multiple myeloma, mantle cell lymphoma

AE: Peripheral neuropathy, herpes zoster

17
Q

Tamoxifen, raloxifene

A

Mech: Selective estrogen receptor modulator - receptor antagonists in breast and agonists in bone. BLock the binding of estrogen in ER+ cells

Use: Breast cancer treatment and prevention. Raloxefene is used to prevent osteoporosis

18
Q

Trastuzumab

A

Mech: Monoclonal antibody against HER2, a tyrosine kinase receptor

Use: Her2 + breast cancer and gastric cancer

AE: Cardiotoxicity “Heartceptin” damages the heart

19
Q

Vemurafenib

A

Small molecule inhibitor of BRAF + melanoma V600E mutated BRAF inhibition

Use: Metastatic melanoma

20
Q

Rasburicase

A

Recombinant uricase that catalyzes metabolism of uric acid into Allentoin

Prevention and treatment of tumor lysis syndrome

21
Q

Bosentan

A

Competitively antagonizes ENdothelin 1 decreasing pulmonary vascular resistance

AE: Hepatotoxic

Pharm Formulas (10 decks)

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