imt

Question 1

mtx SE 5, MOA

Answer 1

N/V, ulcerative stomatitis, liver, BMT, lymphoma; folate antagonist (metabolized by liver)

Question 2

mycophenolate SE 1, MOA

Answer 2

GI/N/V, inhibits purine metabolism, metabolized by liver

Question 3

azathioprine SE 4, MOA

Answer 3

GI, BMT, hepatitis, pancreatitis; antimetabolite purine analogue (kidney excretion)

Question 4

cyclosporine A SE 6, MOA

Answer 4

htn, kidneys, HLD, DM, hyperuricemia, hyperplasia gum; calcineurin inhibitor (metabolized by liver)

Question 5

tacrolimus SE, MOA

Answer 5

similar to cyclosporine including kidney, HLD, DM, hyperuricemia; calcineurin inhibitor

Question 6

sirolimus SE 2, MOA

Answer 6

GI distress, skin disorders; mTOR inhibitor

Question 7

cyclophosphamide SE 5, MOA

Answer 7

alopecia, hemorrhagic cystitis, BMT, sterility, malignancy; causes DNA cross linking (alkylating agent, liver metabolism)

Question 8

chlorambucil SE 3, MOA

Answer 8

BMT, sterility, malignancy; dna cross linking alkylating agent, liver

Question 9

infliximab SE 5, MOA

Answer 9

Tb reactivation, remicade reaction (type 1 sx), skin cancers, lupus, CHF; tnf alpha inhibitor (reticuloendothelial metabolism but don’t use with hep B, also tb/MS)

Question 10

adalimumab (humira) SE 5, MOA

Answer 10

pain at injection site, anaphylaxis, drug induced lupus, demyelinating, GI; tnf alpha antibody (tb, MS)

Question 11

golimumab SE 4, MOA

Answer 11

TB, secondary lymphoma, anaphylaxis, HF; tnf alpha antibody (tb, MS)

Question 12

rituximab SE 5, MOA

Answer 12

fatal infusion reactions, PML, arrhythmia, hepatitis B, SJS; anti cd20

Question 13

tocilizumab moa

Answer 13

IL6 antagonist