IMPUSLE 2

Question 1

GIRLS with ADHD tend to have what predominant symptoms?

Answer 1

INATTENTIVENESS

Question 2

what percent of children with ADHD go onto adult ADHD?

Answer 2

60%

Question 3

What is the gender difference in prevalence of Tourettes?

Answer 3

M>F

Question 4

What do PET studies suggest about the pathophysiology of Tourettes?

Answer 4

Increased DA activity in Ventral Striatum

AND

Abnormal release and uptake of DA.

Question 5

Dopaminergic neurons in what part of the brain is linked with Tourettes and development of motor tics?

How?

Answer 5

DA neurons in Caudate Nucleus

Caudate D2 receptor overstimulation causes tics and movements

Question 6

What is the most common congenital viral infection in new borns?

Answer 6

CMV

Question 7

Most infants with inutero CMV infections…what symptoms can they have?

Answer 7

1. Microcephaly
2. Hepatosplenomegaly
3. Jaundice
4. Chorioretinitis
5. Ataxia
6. Seizures

Question 8

What ADHD medication would you consider when treating ADHD in a person with comorbid TIC disorder?

What is the MOA of this drug?

Answer 8

Atomoxatine (Stratera) = Selective NE reuptake inhinitor (not a stimulant)

(Stimulant ADHD medication will worsen TICS)

Question 9

What is the diagnostic criteria for intermittent explosive disorder?

Answer 9

1. Recurrent behavioral outbursts (either verbal or physical to person/property) due to failure to control aggressive impulses.
2. Aggression grossly out of proportion to trigger
3. Outburst NOT premeditated and unpredictable.
4. Only diagnosed after 6 year of age or older.

Question 10

Intermittent explosive disorder is highly comorbid with what 3 illnesses or behaviors?

What is the mainstay of treatments?

Answer 10

1. Fire setting
2. Eating disorders
3. Substance use

Treatments: Mood stabilizers (Lithium, VPA, Carbamazepine, Gabapentin) and SSRI/TCAs.