Important Molecules and Definitions

Question 1

Lamellar Granules

Answer 1

Contribute to skin adhesion and impermeability

• Between the stratum granulosum and stratum corneum
• Form abnormally in absence of critical ceramides

Question 2

Ceramides (Glucosylceramide)

Answer 2

(A glycolipid) that contributes to water-barrier function of the skin

Question 3

Desmosomal adhesion depends on which molecules:

Answer 3

1. Cadherins
2. Calcium-Dependent Desmogleins
3. Calcium-Dependent Desmocollins

Question 4

Desmogleins

Answer 4

Fxn in cell adhesion and differentiation
-Binding of desmoglein 1 cytoplasmic tail to the scaffolding-protein Erbin down regulates the Ras-Raf pathway to PROMOTE stratification and differentiation of keratinocytes in the epidermis