Important Cytokines Flashcards
IL-1
Secreted by macrophages. Pyrogen -> fever. Causes acute inflammation. Increases endothelial adhesion molecules. Induces chemokine secretion.
IL-6
Secreted by macrophages and Th2 cells. Fever. Stimulates production of acute phase proteins.
IL-8
Secreted by macrophages. Major chemotactic factor for neutrophils (others: CILK -> C5a, IL-8, LTB4, Kallikrein)
IL-12
Secreted by macrophages and B cells. Induces differentiation of T cells into Th1 cells. Also activates NK cells.
TNF alpha
Secreted by macrophages. An acute phase reactant. Fever, septic shock, activates endothelium-> leukocyte recruitment, vascular leakage.
IL-2
Secreted by all T cells but esp. Th1 cells. Stimulates growth of CD4, CD8, and T-regs but esp. CD8+ cytotoxic T-cells.
IL-3
Secreted by all T cells. Supports the growth and differentiation of BONE marrow stem cells. Functions like GM-CSF.
IFN gamma
Secreted from Th1 cells. Activates macrophages and Th1 cells. Suppresses Th2 cells. Has antiviral and anti-tumor properties.
IL-4
Secreted from Th2 cells. Induces differentiation into Th2 cells. Promotes growth of B cells. Enhances class switching to IgE and IgG.
IL-5.
Secreted by Th2 cells. “Snot producing IL.” Promotes differentiation of B cells. Enhances class switching to IgA (found in mucous and secretions -> snot). Stimulates growth and differentiation of eosinophils (seen in allergies and asthma both of which have a lot of mucous!!)
IL-10
Secreted by Th2 cells and regulatory T cells. Inhibits macrophage cytokine release. Inhibits actions of activated T cells and Th1 cells. TGF beta has similar actions to IL-10 b/c it is involved in inhibiting inflammation
What is the pneumonic for the first 5 cytokines. What does it stand for?
Hot T-Bone GamE stEAk IL-1: fever (hot) IL-2: stimulates T cells IL-3: stimulates Bone marrow IL-4: stimulates IgG and IgE IL-5: stimulates Eosinophils and IgA
