Immunosuppressants quiz Flashcards
1
Q
Precursor of 6-mercaptopurine
A
Azathioprine
2
Q
may prevent its side effect of neurotoxicity with mannitol diuresis
A
Cyclosporine
3
Q
antibody that binds to CD3 on T-cells
A
Muromonab
4
Q
antibody that binds IL-2 receptor on activated T cells
A
Daclizumab
5
Q
Inhibits inosine monophosphate dehydrogenase
A
Mycophenolate
6
Q
Binds cyclophilins -> Inhibits calcineurin -> loss of IL-2 production -> blockage of T cell differentiation and activation
A
Cylcosporine
7
Q
binds FK binding protein -> loss of IL-2 production
A
Tacrolimus
8
Q
binds FKBP-12 -> inhibition of mTOR-> inhibition of T-cell proliferation
A
Sirolimus
9
Q
Used for lupus nephritis
A
Mycophenolate
10
Q
Metabolized by xanthine oxidase
A
Azathioprine
