Implantation Flashcards

1
Q

How much time does the embryo spend in the fallopian tube?

A

3 days

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is the blastocoele?

A

The vacuolized space adjacent to the inner cell mass

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is decidualization?

A

The morphological and biochemical differentiation of uterine stroma

It is characterized by the accumulation of glycogen and lipds, activation of COX-2, recruitment of dNK cells, and production of prolactin and IGFBP-1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

COX-2 stimulates increased synthesis of _________.

A

PGE2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

It’s thought that decidualization results from __________ signalling.

A

progesterone and estrogen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Trophoblasts secrete __________.

A

bHCG

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

True or false: the zona pellucida merges with the endometrium.

A

False. The blastocyst “hatches” on day 5 from the zona pellucida and implants in the endometrium. It is believed that there is a lytic agent in the uterine cavity that causes this. This depends on a morula/blastocyst - unfertilized eggs dont hatch

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

When (in the cycle) is the uterus receptive for implantation?

A

Day 20-24

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What are pinopods?

A

Microvilli on the endometrial surface that aid in implantation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

The first step in implantation is _______________.

A

apposition

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

The uterine stroma just deep to the embryo is called the ___________ and the uterine stroma just superficial to the embryo is called the __________ and the uterine stroma next to the myometrium is called the _________.

A

decidua basalis; decidua capsularis, decidua parietalis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Where is the most common site of implantation?

A

The posterior wall of the uterus, just superior to the fundus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

______________ is when the placenta obscures the cervix.

A

Placenta previa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is placenta accreta?

A

When the placenta grows deep into the walls of the uterus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

The leading cause of maternal death in the first trimester is _____________.

A

ectopic pregnancy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

When do serum hCG tests become positive?

A

About three weeks after her last period (urine tests are four weeks)

17
Q

At what beta-hCG value should you be able to see an intrauterine pregnancy on ultrasound?

A

1,500

18
Q

When, in the gestational age of the embryo, does implantation occur?

A

Day 6-7

19
Q

_____________ also has immunosuppressive qualities.

A

Beta hCG

20
Q

After the interdigitation involved in apposition, the trophectoderm interacts with ___________ receptors on the endometrium in a process called adhesion.

A

integrin

21
Q

The syncytiotrophoblasts secrete TNF-alpha from their protrusions which ______________.

A

causes the down-regulation of cadherins that allows for placental invasion

22
Q

What often causes placenta accreta?

A

Implantation on the site of a uterine scar

23
Q

What stage follows adhesion?

A

Invasion

24
Q

what are the 3 stages of implantation

A

1) apposition
2) adhesion
3) invasion

25
Q

what prevents immune rejection of the fetus?

A
  • syncytiotrophoblasts lack MHC antigens
  • extravillous trophoblast contain special HLA antigens (HLA-G may down-regulate t cell and NK cell activation in the local placental environment)
26
Q

risk factors for ectopic pregnancy

A

tubal disease, prior eptopic, infertility and ART, smoking, vaginal douching