Impacts of Genomics on Clinical Medicine

Question 1

Indidence increasing in type 2 diabetes by what factor ?

Answer 1

Industrialized world

Obesity

Question 2

Estrogen what become high it indicates?

Answer 2

Cancer

Question 3

Compare between genetic and genomic ?

Answer 3

Genetic vs Genomic
An effect that is significant enough to interpret by itself

Mutation
Pathological
Unique or rare

An effect that can omnly be interpreted correctly in the context other similar variants

Variant or polymorphism
Normal
Commo

Question 4

Chronic illness with an array of complicating ?

Answer 4

Microvascular

Macro-vascular

Question 5

Percentage of identical at the DNA sequence level ?

Answer 5

99.6%

Question 6

Percentage of the similarity with mouse and chimp?

Answer 6

Mouse 70.90%

Chimp98.5%

Question 7

Sources of genetic variation ?

Answer 7

1-Insertion /deletion indels
2-Length polymorphism STRp

3-Single nucleotide polymorphism SNPs the high 45%

4-Copy number variants CNVs

5-Inversions

6-Recombination

Question 8

How much human variation differ ?

Answer 8

1/1000 bp

Question 9

Some genes with positive selection around the time of divergence ?

Answer 9

1 -DYRKIA cognition
2-THADA energy metab
3-NRG3 neurodevelopment
4- several microRNA s

Question 10

Microarrays Required advances in?

Answer 10

• DNA amplification
• Robotics Microengineering
• Florescent probes
• Bioinformatics / computing

Question 11

Risk of Breast Cancer in the Population percentage of polygenic risk ?

Answer 11

Top 25% Polygenic Risk

Question 12

Properties of Next generation Sequencing?

Answer 12

Massive Increase in sequencing capacity

Question 13

What is the Cytochrome? With example

Answer 13

Responsible for metabolizing nearly 25% of all drugs

CYP2D6

Question 14

Some CYP2D6 Drugs?

Answer 14

• Beta blockers, eg propanaolol, nifedipine
• Tricylclics antidepressants
• SSRIs (eg paroxetine, fluoxetine) (Selective serotonin reuptake
inhibitors)
• Anti-psychotics (haloperidol, risperidone, thioridazine)
• others: Codeine, Amphetamine, Tamoxifen

Question 15

Metastatic esophageal cancer because of mutation in ?

Answer 15

bar abl kinase gene

Question 16

Treatment of Metastatic esophageal cancer by ?

Answer 16

Imatinib

Question 17

Toungue adenocarcinoma treats by ?

Answer 17

RET